Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis
Background: Clinical High Risk (CHS) for psychosis is a state in which positive symptoms are predominant but do not reach a level of severity that fulfils the criteria for a psychotic episode. The aim of this study has been to investigate whether cognition in subjects with newly detected CHR affects...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Schizophrenia Research: Cognition |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215001321000172 |
| _version_ | 1818717167131033600 |
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| author | Ingvild Aase Johannes Hendrik Langeveld Jan Olav Johannessen Inge Joa Ingvild Dalen Wenche ten Velden Hegelstad |
| author_facet | Ingvild Aase Johannes Hendrik Langeveld Jan Olav Johannessen Inge Joa Ingvild Dalen Wenche ten Velden Hegelstad |
| author_sort | Ingvild Aase |
| collection | DOAJ |
| description | Background: Clinical High Risk (CHS) for psychosis is a state in which positive symptoms are predominant but do not reach a level of severity that fulfils the criteria for a psychotic episode. The aim of this study has been to investigate whether cognition in subjects with newly detected CHR affects the longitudinal development of positive symptoms. Methods: Fifty-three CHR individuals fulfilling the criteria for attenuated positive syndrome in the Structural Interview for Prodromal Syndromes (SIPS) were included. At inclusion, all participants completed a neurocognitive battery consisting of tests measuring attention, verbal memory, verbal fluency, executive functions and general intelligence. Cognitive domain z-scores were defined by contrasting with observed scores of a group of matched healthy controls (n = 40). Associations between cognitive performance at inclusion and longitudinal measures of positive symptoms were assessed by using generalised linear models including non-linear effects of time. All regression models were adjusted for age and gender. Results: Overall, SIPS positive symptoms declined over the time period, with a steeper decline during the first six months. Deficits in executive functions were assossiated witn a higher load of positive symptoms at baseline (p=0.006), but also to a faster improvement (p=0.030), wheras those with poor verbal fluency improved more slowly (p=0.018). Conclusion: To our knowledge, this is the first study that follows CHR subjects by means of frequent clinical interviews over a sustained period of time. The study provides evidence of an association between executive functions, including verbal fluency, with the evolvement of positive symptoms. |
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| format | Article |
| id | doaj.art-e2648b418b46427d9d11be33696971a8 |
| institution | Directory Open Access Journal |
| issn | 2215-0013 |
| language | English |
| last_indexed | 2024-12-17T19:30:51Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Schizophrenia Research: Cognition |
| spelling | doaj.art-e2648b418b46427d9d11be33696971a82022-12-21T21:35:16ZengElsevierSchizophrenia Research: Cognition2215-00132021-12-0126100210Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosisIngvild Aase0Johannes Hendrik Langeveld1Jan Olav Johannessen2Inge Joa3Ingvild Dalen4Wenche ten Velden Hegelstad5TIPS Center for Clinical Research in Psychosis, Clinic for Adult Mental Health Care, Stavanger University Hospital, P.O. 8100, 4068 Stavanger, Norway; Faculty of Health Sciences, University of Stavanger, 4036 Stavanger, Norway; Corresponding author.TIPS Center for Clinical Research in Psychosis, Clinic for Adult Mental Health Care, Stavanger University Hospital, P.O. 8100, 4068 Stavanger, Norway; Faculty of Health Sciences, University of Stavanger, 4036 Stavanger, NorwayTIPS Center for Clinical Research in Psychosis, Clinic for Adult Mental Health Care, Stavanger University Hospital, P.O. 8100, 4068 Stavanger, Norway; Faculty of Health Sciences, University of Stavanger, 4036 Stavanger, NorwayTIPS Center for Clinical Research in Psychosis, Clinic for Adult Mental Health Care, Stavanger University Hospital, P.O. 8100, 4068 Stavanger, Norway; Faculty of Health Sciences, University of Stavanger, 4036 Stavanger, NorwayFaculty of Health Sciences, University of Stavanger, 4036 Stavanger, Norway; Research Department, Stavanger University Hospital, P. O. 8100, 4068 Stavanger, NorwayTIPS Center for Clinical Research in Psychosis, Clinic for Adult Mental Health Care, Stavanger University Hospital, P.O. 8100, 4068 Stavanger, Norway; Faculty of Social Sciences, University of Stavanger, 4036 Stavanger, NorwayBackground: Clinical High Risk (CHS) for psychosis is a state in which positive symptoms are predominant but do not reach a level of severity that fulfils the criteria for a psychotic episode. The aim of this study has been to investigate whether cognition in subjects with newly detected CHR affects the longitudinal development of positive symptoms. Methods: Fifty-three CHR individuals fulfilling the criteria for attenuated positive syndrome in the Structural Interview for Prodromal Syndromes (SIPS) were included. At inclusion, all participants completed a neurocognitive battery consisting of tests measuring attention, verbal memory, verbal fluency, executive functions and general intelligence. Cognitive domain z-scores were defined by contrasting with observed scores of a group of matched healthy controls (n = 40). Associations between cognitive performance at inclusion and longitudinal measures of positive symptoms were assessed by using generalised linear models including non-linear effects of time. All regression models were adjusted for age and gender. Results: Overall, SIPS positive symptoms declined over the time period, with a steeper decline during the first six months. Deficits in executive functions were assossiated witn a higher load of positive symptoms at baseline (p=0.006), but also to a faster improvement (p=0.030), wheras those with poor verbal fluency improved more slowly (p=0.018). Conclusion: To our knowledge, this is the first study that follows CHR subjects by means of frequent clinical interviews over a sustained period of time. The study provides evidence of an association between executive functions, including verbal fluency, with the evolvement of positive symptoms.http://www.sciencedirect.com/science/article/pii/S2215001321000172Clinical high risk for psychosisPositive symptomsCognitive predictorsVerbal fluencyExecutive functionsLongitudinal |
| spellingShingle | Ingvild Aase Johannes Hendrik Langeveld Jan Olav Johannessen Inge Joa Ingvild Dalen Wenche ten Velden Hegelstad Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis Schizophrenia Research: Cognition Clinical high risk for psychosis Positive symptoms Cognitive predictors Verbal fluency Executive functions Longitudinal |
| title | Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis |
| title_full | Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis |
| title_fullStr | Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis |
| title_full_unstemmed | Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis |
| title_short | Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis |
| title_sort | cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis |
| topic | Clinical high risk for psychosis Positive symptoms Cognitive predictors Verbal fluency Executive functions Longitudinal |
| url | http://www.sciencedirect.com/science/article/pii/S2215001321000172 |
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