Disease Modeling with Kidney Organoids
Kidney diseases often lack optimal treatments, causing millions of deaths each year. Thus, developing appropriate model systems to study human kidney disease is of utmost importance. Some of the most promising human kidney models are organoids or small organ-resembling tissue collectives, derived fr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/13/9/1384 |
| _version_ | 1827658768893083648 |
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| author | Sophie Karp Martin R Pollak Balajikarthick Subramanian |
| author_facet | Sophie Karp Martin R Pollak Balajikarthick Subramanian |
| author_sort | Sophie Karp |
| collection | DOAJ |
| description | Kidney diseases often lack optimal treatments, causing millions of deaths each year. Thus, developing appropriate model systems to study human kidney disease is of utmost importance. Some of the most promising human kidney models are organoids or small organ-resembling tissue collectives, derived from human-induced pluripotent stem cells (hiPSCs). However, they are more akin to a first-trimester fetal kidney than an adult kidney. Therefore, new strategies are needed to advance their maturity. They have great potential for disease modeling and eventually auxiliary therapy if they can reach the maturity of an adult kidney. In this review, we will discuss the current state of kidney organoids in terms of their similarity to the human kidney and use as a disease modeling system thus far. We will then discuss potential pathways to advance the maturity of kidney organoids to match an adult kidney for more accurate human disease modeling. |
| first_indexed | 2024-03-09T23:09:17Z |
| format | Article |
| id | doaj.art-e2652e6f25b948f6a58a8927dd277553 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T23:09:17Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-e2652e6f25b948f6a58a8927dd2775532023-11-23T17:48:37ZengMDPI AGMicromachines2072-666X2022-08-01139138410.3390/mi13091384Disease Modeling with Kidney OrganoidsSophie Karp0Martin R Pollak1Balajikarthick Subramanian2Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USADivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USADivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USAKidney diseases often lack optimal treatments, causing millions of deaths each year. Thus, developing appropriate model systems to study human kidney disease is of utmost importance. Some of the most promising human kidney models are organoids or small organ-resembling tissue collectives, derived from human-induced pluripotent stem cells (hiPSCs). However, they are more akin to a first-trimester fetal kidney than an adult kidney. Therefore, new strategies are needed to advance their maturity. They have great potential for disease modeling and eventually auxiliary therapy if they can reach the maturity of an adult kidney. In this review, we will discuss the current state of kidney organoids in terms of their similarity to the human kidney and use as a disease modeling system thus far. We will then discuss potential pathways to advance the maturity of kidney organoids to match an adult kidney for more accurate human disease modeling.https://www.mdpi.com/2072-666X/13/9/1384organoidskidneydevelopmentmetanephrosureterictubule |
| spellingShingle | Sophie Karp Martin R Pollak Balajikarthick Subramanian Disease Modeling with Kidney Organoids Micromachines organoids kidney development metanephros ureteric tubule |
| title | Disease Modeling with Kidney Organoids |
| title_full | Disease Modeling with Kidney Organoids |
| title_fullStr | Disease Modeling with Kidney Organoids |
| title_full_unstemmed | Disease Modeling with Kidney Organoids |
| title_short | Disease Modeling with Kidney Organoids |
| title_sort | disease modeling with kidney organoids |
| topic | organoids kidney development metanephros ureteric tubule |
| url | https://www.mdpi.com/2072-666X/13/9/1384 |
| work_keys_str_mv | AT sophiekarp diseasemodelingwithkidneyorganoids AT martinrpollak diseasemodelingwithkidneyorganoids AT balajikarthicksubramanian diseasemodelingwithkidneyorganoids |