Microstructural alterations of major thalamic nuclei in the chronic pediatric spinal cord injured population
Background: The brain undergoes reorganization following spinal cord injury (SCI), but little is known about how the thalamus is affected in pediatric SCIs. Purpose: To characterize microstructural alterations in the thalamus after SCI with diffusion tensor imaging (DTI) metrics. Methods: 18 pediatr...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | World Neurosurgery: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590139723001175 |
| _version_ | 1797320929273970688 |
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| author | K. Kang K. Fleming A. Sathe J. Muller J. Harrop D. Middleton J.E. Heller A. Sharan F. Mohamed L. Krisa M. Alizadeh |
| author_facet | K. Kang K. Fleming A. Sathe J. Muller J. Harrop D. Middleton J.E. Heller A. Sharan F. Mohamed L. Krisa M. Alizadeh |
| author_sort | K. Kang |
| collection | DOAJ |
| description | Background: The brain undergoes reorganization following spinal cord injury (SCI), but little is known about how the thalamus is affected in pediatric SCIs. Purpose: To characterize microstructural alterations in the thalamus after SCI with diffusion tensor imaging (DTI) metrics. Methods: 18 pediatric participants with chronic SCI (8–20 years) were stratified using the American Spinal Injury Association Impairment Scale (AIS) into groups: A, B, and C/D. DTI of the brain used a 3 T Siemens Verio MRI using the parameters: 20 directions, number of averages = 3, b = 1000 s/mm2, voxel size = 1.8 mm × 1.8 mm, slice thickness = 5 mm, TE = 95 ms, TR = 4300 ms, 30 slices, FOV = 230 × 230 mm2, matrix = 128 × 128, acquisition time = 4:45 min. Diffusion data was processed to generate DTI metrics FA, MD, AD, and RD. Data analysis: DTI metrics were acquired by superimposing the AAL3 thalamic atlas onto participant diffusion images registered to MNI152 space. We utilized a multiple Mann–Whitney U-test to compare between AIS groups, considering values of p ≤ 0.05 as significant. Results: FA, AD, RD, and MD significantly differed in thalamic nuclei between AIS groups A vs B and B vs C/D. Significant nuclei include the right ventral anterior, left intralaminar, bilateral lateral pulvinar, and right lateral geniculate. Conclusion: Our findings suggest the presence of microstructural alterations based on SCI severity in pediatric patients. These results are encouraging and warrant further study. |
| first_indexed | 2024-03-08T04:50:07Z |
| format | Article |
| id | doaj.art-e26b10f39b224dbe88560f6bcab7ed4d |
| institution | Directory Open Access Journal |
| issn | 2590-1397 |
| language | English |
| last_indexed | 2024-03-08T04:50:07Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Neurosurgery: X |
| spelling | doaj.art-e26b10f39b224dbe88560f6bcab7ed4d2024-02-08T05:16:00ZengElsevierWorld Neurosurgery: X2590-13972024-01-0121100268Microstructural alterations of major thalamic nuclei in the chronic pediatric spinal cord injured populationK. Kang0K. Fleming1A. Sathe2J. Muller3J. Harrop4D. Middleton5J.E. Heller6A. Sharan7F. Mohamed8L. Krisa9M. Alizadeh10Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USA; Corresponding author.Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USAJefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USAJefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USADepartment of Neurosurgery, Thomas Jefferson University, 909 Walnut Street, 2nd Floor, Philadelphia, PA, 19107, USAJefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USADepartment of Neurosurgery, Thomas Jefferson University, 909 Walnut Street, 2nd Floor, Philadelphia, PA, 19107, USADepartment of Neurosurgery, Thomas Jefferson University, 909 Walnut Street, 2nd Floor, Philadelphia, PA, 19107, USAJefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USAJefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USADepartment of Neurosurgery, Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USABackground: The brain undergoes reorganization following spinal cord injury (SCI), but little is known about how the thalamus is affected in pediatric SCIs. Purpose: To characterize microstructural alterations in the thalamus after SCI with diffusion tensor imaging (DTI) metrics. Methods: 18 pediatric participants with chronic SCI (8–20 years) were stratified using the American Spinal Injury Association Impairment Scale (AIS) into groups: A, B, and C/D. DTI of the brain used a 3 T Siemens Verio MRI using the parameters: 20 directions, number of averages = 3, b = 1000 s/mm2, voxel size = 1.8 mm × 1.8 mm, slice thickness = 5 mm, TE = 95 ms, TR = 4300 ms, 30 slices, FOV = 230 × 230 mm2, matrix = 128 × 128, acquisition time = 4:45 min. Diffusion data was processed to generate DTI metrics FA, MD, AD, and RD. Data analysis: DTI metrics were acquired by superimposing the AAL3 thalamic atlas onto participant diffusion images registered to MNI152 space. We utilized a multiple Mann–Whitney U-test to compare between AIS groups, considering values of p ≤ 0.05 as significant. Results: FA, AD, RD, and MD significantly differed in thalamic nuclei between AIS groups A vs B and B vs C/D. Significant nuclei include the right ventral anterior, left intralaminar, bilateral lateral pulvinar, and right lateral geniculate. Conclusion: Our findings suggest the presence of microstructural alterations based on SCI severity in pediatric patients. These results are encouraging and warrant further study.http://www.sciencedirect.com/science/article/pii/S2590139723001175Spinal cord injuryDiffusion tensor imagingThalamusPediatricsMagnetic resonance imaging |
| spellingShingle | K. Kang K. Fleming A. Sathe J. Muller J. Harrop D. Middleton J.E. Heller A. Sharan F. Mohamed L. Krisa M. Alizadeh Microstructural alterations of major thalamic nuclei in the chronic pediatric spinal cord injured population World Neurosurgery: X Spinal cord injury Diffusion tensor imaging Thalamus Pediatrics Magnetic resonance imaging |
| title | Microstructural alterations of major thalamic nuclei in the chronic pediatric spinal cord injured population |
| title_full | Microstructural alterations of major thalamic nuclei in the chronic pediatric spinal cord injured population |
| title_fullStr | Microstructural alterations of major thalamic nuclei in the chronic pediatric spinal cord injured population |
| title_full_unstemmed | Microstructural alterations of major thalamic nuclei in the chronic pediatric spinal cord injured population |
| title_short | Microstructural alterations of major thalamic nuclei in the chronic pediatric spinal cord injured population |
| title_sort | microstructural alterations of major thalamic nuclei in the chronic pediatric spinal cord injured population |
| topic | Spinal cord injury Diffusion tensor imaging Thalamus Pediatrics Magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2590139723001175 |
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