Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli
The bacterium E. coli has around 300 transcriptional factors, but the functions of many of them, and the interactions between their respective regulatory networks, are unclear. Here, the authors study genetic interactions among all transcription factor genes in E. coli, revealing condition-dependent...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31819-x |
| _version_ | 1811294591771475968 |
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| author | Alla Gagarinova Ali Hosseinnia Matineh Rahmatbakhsh Zoe Istace Sadhna Phanse Mohamed Taha Moutaoufik Mara Zilocchi Qingzhou Zhang Hiroyuki Aoki Matthew Jessulat Sunyoung Kim Khaled A. Aly Mohan Babu |
| author_facet | Alla Gagarinova Ali Hosseinnia Matineh Rahmatbakhsh Zoe Istace Sadhna Phanse Mohamed Taha Moutaoufik Mara Zilocchi Qingzhou Zhang Hiroyuki Aoki Matthew Jessulat Sunyoung Kim Khaled A. Aly Mohan Babu |
| author_sort | Alla Gagarinova |
| collection | DOAJ |
| description | The bacterium E. coli has around 300 transcriptional factors, but the functions of many of them, and the interactions between their respective regulatory networks, are unclear. Here, the authors study genetic interactions among all transcription factor genes in E. coli, revealing condition-dependent interactions and roles for uncharacterized transcription factors. |
| first_indexed | 2024-04-13T05:19:42Z |
| format | Article |
| id | doaj.art-e26b507a74f145268dd8fb6fa76b67a2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T05:19:42Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e26b507a74f145268dd8fb6fa76b67a22022-12-22T03:00:48ZengNature PortfolioNature Communications2041-17232022-07-0113111610.1038/s41467-022-31819-xAuxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coliAlla Gagarinova0Ali Hosseinnia1Matineh Rahmatbakhsh2Zoe Istace3Sadhna Phanse4Mohamed Taha Moutaoufik5Mara Zilocchi6Qingzhou Zhang7Hiroyuki Aoki8Matthew Jessulat9Sunyoung Kim10Khaled A. Aly11Mohan Babu12Department of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaDepartment of Biochemistry, University of ReginaThe bacterium E. coli has around 300 transcriptional factors, but the functions of many of them, and the interactions between their respective regulatory networks, are unclear. Here, the authors study genetic interactions among all transcription factor genes in E. coli, revealing condition-dependent interactions and roles for uncharacterized transcription factors.https://doi.org/10.1038/s41467-022-31819-x |
| spellingShingle | Alla Gagarinova Ali Hosseinnia Matineh Rahmatbakhsh Zoe Istace Sadhna Phanse Mohamed Taha Moutaoufik Mara Zilocchi Qingzhou Zhang Hiroyuki Aoki Matthew Jessulat Sunyoung Kim Khaled A. Aly Mohan Babu Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli Nature Communications |
| title | Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli |
| title_full | Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli |
| title_fullStr | Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli |
| title_full_unstemmed | Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli |
| title_short | Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli |
| title_sort | auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in escherichia coli |
| url | https://doi.org/10.1038/s41467-022-31819-x |
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