Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process
G protein-coupled receptors (GPCRs) represent one of the most functionally diverse classes of transmembrane proteins. GPCRs and their associated signaling systems have been linked to nearly every physiological process. They also constitute nearly 40% of the current pharmacopeia as direct targets of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/13598 |
| _version_ | 1797467885204930560 |
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| author | Stuart Maudsley Deborah Walter Claudia Schrauwen Nore Van Loon İrem Harputluoğlu Julia Lenaerts Patricia McDonald |
| author_facet | Stuart Maudsley Deborah Walter Claudia Schrauwen Nore Van Loon İrem Harputluoğlu Julia Lenaerts Patricia McDonald |
| author_sort | Stuart Maudsley |
| collection | DOAJ |
| description | G protein-coupled receptors (GPCRs) represent one of the most functionally diverse classes of transmembrane proteins. GPCRs and their associated signaling systems have been linked to nearly every physiological process. They also constitute nearly 40% of the current pharmacopeia as direct targets of remedial therapies. Hence, their place as a functional nexus in the interface between physiological and pathophysiological processes suggests that GPCRs may play a central role in the generation of nearly all types of human disease. Perhaps one mechanism through which GPCRs can mediate this pivotal function is through the control of the molecular aging process. It is now appreciated that, indeed, many human disorders/diseases are induced by GPCR signaling processes linked to pathological aging. Here we discuss one such novel member of the GPCR family, GPR19, that may represent an important new target for novel remedial strategies for the aging process. The molecular signaling pathways (metabolic control, circadian rhythm regulation and stress responsiveness) associated with this recently characterized receptor suggest an important role in aging-related disease etiology. |
| first_indexed | 2024-03-09T19:00:06Z |
| format | Article |
| id | doaj.art-e26d29dd5ea649d086929f88f3aacc54 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:00:06Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e26d29dd5ea649d086929f88f3aacc542023-11-24T05:10:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123211359810.3390/ijms232113598Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging ProcessStuart Maudsley0Deborah Walter1Claudia Schrauwen2Nore Van Loon3İrem Harputluoğlu4Julia Lenaerts5Patricia McDonald6Receptor Biology Lab, University of Antwerp, 2610 Antwerpen, BelgiumReceptor Biology Lab, University of Antwerp, 2610 Antwerpen, BelgiumReceptor Biology Lab, University of Antwerp, 2610 Antwerpen, BelgiumReceptor Biology Lab, University of Antwerp, 2610 Antwerpen, BelgiumReceptor Biology Lab, University of Antwerp, 2610 Antwerpen, BelgiumReceptor Biology Lab, University of Antwerp, 2610 Antwerpen, BelgiumMoffitt Cancer Center, Tampa, FL 33612, USAG protein-coupled receptors (GPCRs) represent one of the most functionally diverse classes of transmembrane proteins. GPCRs and their associated signaling systems have been linked to nearly every physiological process. They also constitute nearly 40% of the current pharmacopeia as direct targets of remedial therapies. Hence, their place as a functional nexus in the interface between physiological and pathophysiological processes suggests that GPCRs may play a central role in the generation of nearly all types of human disease. Perhaps one mechanism through which GPCRs can mediate this pivotal function is through the control of the molecular aging process. It is now appreciated that, indeed, many human disorders/diseases are induced by GPCR signaling processes linked to pathological aging. Here we discuss one such novel member of the GPCR family, GPR19, that may represent an important new target for novel remedial strategies for the aging process. The molecular signaling pathways (metabolic control, circadian rhythm regulation and stress responsiveness) associated with this recently characterized receptor suggest an important role in aging-related disease etiology.https://www.mdpi.com/1422-0067/23/21/13598GPR19GPCRagingtherapeuticslongevitystress |
| spellingShingle | Stuart Maudsley Deborah Walter Claudia Schrauwen Nore Van Loon İrem Harputluoğlu Julia Lenaerts Patricia McDonald Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process International Journal of Molecular Sciences GPR19 GPCR aging therapeutics longevity stress |
| title | Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process |
| title_full | Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process |
| title_fullStr | Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process |
| title_full_unstemmed | Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process |
| title_short | Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process |
| title_sort | intersection of the orphan g protein coupled receptor gpr19 with the aging process |
| topic | GPR19 GPCR aging therapeutics longevity stress |
| url | https://www.mdpi.com/1422-0067/23/21/13598 |
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