Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis.
Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulat...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC3591311?pdf=render |
| _version_ | 1819121222947962880 |
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| author | Lucja A Labuda Ulysse Ateba-Ngoa Eliane Ngoune Feugap Jorn J Heeringa Luciën E P M van der Vlugt Regina B A Pires Ludovic Mewono Peter G Kremsner Menno C van Zelm Ayola A Adegnika Maria Yazdanbakhsh Hermelijn H Smits |
| author_facet | Lucja A Labuda Ulysse Ateba-Ngoa Eliane Ngoune Feugap Jorn J Heeringa Luciën E P M van der Vlugt Regina B A Pires Ludovic Mewono Peter G Kremsner Menno C van Zelm Ayola A Adegnika Maria Yazdanbakhsh Hermelijn H Smits |
| author_sort | Lucja A Labuda |
| collection | DOAJ |
| description | Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level. |
| first_indexed | 2024-12-22T06:33:08Z |
| format | Article |
| id | doaj.art-e26e231d4abc4bf8bed255d11d2108f4 |
| institution | Directory Open Access Journal |
| issn | 1935-2735 |
| language | English |
| last_indexed | 2024-12-22T06:33:08Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-e26e231d4abc4bf8bed255d11d2108f42022-12-21T18:35:40ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27352013-01-0173e209410.1371/journal.pntd.0002094Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis.Lucja A LabudaUlysse Ateba-NgoaEliane Ngoune FeugapJorn J HeeringaLuciën E P M van der VlugtRegina B A PiresLudovic MewonoPeter G KremsnerMenno C van ZelmAyola A AdegnikaMaria YazdanbakhshHermelijn H SmitsAntibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level.http://europepmc.org/articles/PMC3591311?pdf=render |
| spellingShingle | Lucja A Labuda Ulysse Ateba-Ngoa Eliane Ngoune Feugap Jorn J Heeringa Luciën E P M van der Vlugt Regina B A Pires Ludovic Mewono Peter G Kremsner Menno C van Zelm Ayola A Adegnika Maria Yazdanbakhsh Hermelijn H Smits Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. PLoS Neglected Tropical Diseases |
| title | Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
| title_full | Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
| title_fullStr | Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
| title_full_unstemmed | Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
| title_short | Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
| title_sort | alterations in peripheral blood b cell subsets and dynamics of b cell responses during human schistosomiasis |
| url | http://europepmc.org/articles/PMC3591311?pdf=render |
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