Alpk1 Sensitizes Pancreatic Beta Cells to Cytokine-Induced Apoptosis via Upregulating TNF-α Signaling Pathway

Alpk1 Sensitizes Pancreatic Beta Cells to Cytokine-Induced Apoptosis via Upregulating TNF-α Signaling Pathway

Pancreatic beta cell failure is the hallmark of type 1 diabetes (T1D). Recent studies have suggested that pathogen recognizing receptors (PRRs) are involved in the survival, proliferation and function of pancreatic beta cells. So far, little is known about the role of alpha-protein kinase 1 (ALPK1),...

Full description

Bibliographic Details
Main Authors: Fei Ding, Xi Luo, Yiting Tu, Xianlan Duan, Jia Liu, Lijing Jia, Peilin Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
Alpk1
pancreatic beta cells
apoptosis
pro-inflammatory cytokines
TNF-α signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.705751/full

Similar Items

Similar Items