Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI).
Diagnosing and monitoring recovery of patients with mild traumatic brain injury (mTBI) is challenging because of the lack of objective, quantitative measures. Diagnosis is based on description of injuries often not witnessed, subtle neurocognitive symptoms, and neuropsychological testing. Since work...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5812562?pdf=render |
| _version_ | 1818286161969283072 |
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| author | Xianghong Arakaki Michael Shoga Lianyang Li George Zouridakis Thao Tran Alfred N Fonteh Jessica Dawlaty Robert Goldweber Janice M Pogoda Michael G Harrington |
| author_facet | Xianghong Arakaki Michael Shoga Lianyang Li George Zouridakis Thao Tran Alfred N Fonteh Jessica Dawlaty Robert Goldweber Janice M Pogoda Michael G Harrington |
| author_sort | Xianghong Arakaki |
| collection | DOAJ |
| description | Diagnosing and monitoring recovery of patients with mild traumatic brain injury (mTBI) is challenging because of the lack of objective, quantitative measures. Diagnosis is based on description of injuries often not witnessed, subtle neurocognitive symptoms, and neuropsychological testing. Since working memory (WM) is at the center of cognitive functions impaired in mTBI, this study was designed to define objective quantitative electroencephalographic (qEEG) measures of WM processing that may correlate with cognitive changes associated with acute mTBI. First-time mTBI patients and mild peripheral (limb) trauma controls without head injury were recruited from the emergency department. WM was assessed by a continuous performance task (N-back). EEG recordings were obtained during N-back testing on three occasions: within five days, two weeks, and one month after injury. Compared with controls, mTBI patients showed abnormal induced and evoked alpha activity including event-related desynchronization (ERD) and synchronization (ERS). For induced alpha power, TBI patients had excessive frontal ERD on their first and third visit. For evoked alpha, mTBI patients had lower parietal ERD/ERS at the second and third visits. These exploratory qEEG findings offer new and non-invasive candidate measures to characterize the evolution of injury over the first month, with potential to provide much-needed objective measures of brain dysfunction to diagnose and monitor the consequences of mTBI. |
| first_indexed | 2024-12-13T01:20:12Z |
| format | Article |
| id | doaj.art-e270493fbc814c52b619bdc5be1bd6ee |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T01:20:12Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e270493fbc814c52b619bdc5be1bd6ee2022-12-22T00:04:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01132e018810110.1371/journal.pone.0188101Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI).Xianghong ArakakiMichael ShogaLianyang LiGeorge ZouridakisThao TranAlfred N FontehJessica DawlatyRobert GoldweberJanice M PogodaMichael G HarringtonDiagnosing and monitoring recovery of patients with mild traumatic brain injury (mTBI) is challenging because of the lack of objective, quantitative measures. Diagnosis is based on description of injuries often not witnessed, subtle neurocognitive symptoms, and neuropsychological testing. Since working memory (WM) is at the center of cognitive functions impaired in mTBI, this study was designed to define objective quantitative electroencephalographic (qEEG) measures of WM processing that may correlate with cognitive changes associated with acute mTBI. First-time mTBI patients and mild peripheral (limb) trauma controls without head injury were recruited from the emergency department. WM was assessed by a continuous performance task (N-back). EEG recordings were obtained during N-back testing on three occasions: within five days, two weeks, and one month after injury. Compared with controls, mTBI patients showed abnormal induced and evoked alpha activity including event-related desynchronization (ERD) and synchronization (ERS). For induced alpha power, TBI patients had excessive frontal ERD on their first and third visit. For evoked alpha, mTBI patients had lower parietal ERD/ERS at the second and third visits. These exploratory qEEG findings offer new and non-invasive candidate measures to characterize the evolution of injury over the first month, with potential to provide much-needed objective measures of brain dysfunction to diagnose and monitor the consequences of mTBI.http://europepmc.org/articles/PMC5812562?pdf=render |
| spellingShingle | Xianghong Arakaki Michael Shoga Lianyang Li George Zouridakis Thao Tran Alfred N Fonteh Jessica Dawlaty Robert Goldweber Janice M Pogoda Michael G Harrington Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI). PLoS ONE |
| title | Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI). |
| title_full | Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI). |
| title_fullStr | Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI). |
| title_full_unstemmed | Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI). |
| title_short | Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI). |
| title_sort | alpha desynchronization synchronization during working memory testing is compromised in acute mild traumatic brain injury mtbi |
| url | http://europepmc.org/articles/PMC5812562?pdf=render |
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