Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4

Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4

High concentrations of electrophilic lipid alkenals formed during oxidative stress are implicated in cytotoxicity and disease. However, low concentrations of alkenals are required to induce antioxidative stress responses. An established clearance pathway for lipid alkenals includes conjugation to gl...

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Autors principals: Michele Scian, Lorela Paço, Taylor A. Murphree, Laura M. Shireman, William M. Atkins
Format: Article
Idioma:English
Publicat: MDPI AG 2023-02-01
Col·lecció:Biomolecules
Matèries:
enzyme detoxication
substrate promiscuity
hydroxynonenal
lipid peroxidation
lipid alkenals
enzyme mechanism
Accés en línia:https://www.mdpi.com/2218-273X/13/2/329

Internet

https://www.mdpi.com/2218-273X/13/2/329

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