Signatures of disease progression in knee osteoarthritis: insights from an integrated multi-scale modeling approach, a proof of concept

Signatures of disease progression in knee osteoarthritis: insights from an integrated multi-scale modeling approach, a proof of concept

Introduction: Knee osteoarthritis (KOA) is characterized by articular cartilage degeneration. It has been widely accepted that the mechanical joint environment plays a significant role in the onset and progression of this disease. In silico models have been used to study the interplay between mechan...

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Bibliographic Details
Main Authors: Ikram Mohout, Seyed Ali Elahi, Amir Esrafilian, Bryce A. Killen, Rami K. Korhonen, Sabine Verschueren, Ilse Jonkers
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
osteoarthritis
articular cartilage
finite element modeling
musculoskeletal modeling
adaptive modeling
collagen fibril degeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1214693/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2023.1214693/full

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