High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator
3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. The development of 3D-PACT requires high-performance acoustic sensors with a small size, large detection bandwidth,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2022-01-01
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| Series: | BME Frontiers |
| Online Access: | http://dx.doi.org/10.34133/2022/9891510 |
| _version_ | 1827336690692259840 |
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| author | Qiangzhou Rong Youngseop Lee Yuqi Tang Tri Vu Carlos Taboada Wenhan Zheng Jun Xia David A. Czaplewski Hao F. Zhang Cheng Sun Junjie Yao |
| author_facet | Qiangzhou Rong Youngseop Lee Yuqi Tang Tri Vu Carlos Taboada Wenhan Zheng Jun Xia David A. Czaplewski Hao F. Zhang Cheng Sun Junjie Yao |
| author_sort | Qiangzhou Rong |
| collection | DOAJ |
| description | 3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. The development of 3D-PACT requires high-performance acoustic sensors with a small size, large detection bandwidth, and high sensitivity. In this work, we present a new high-frequency 3D-PACT system that uses a microring resonator (MRR) as the acoustic sensor. The MRR sensor has a size of 80 μm in diameter and was fabricated using the nanoimprint lithography technology. Using the MRR sensor, we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of ~23 MHz, an imaging depth of ~8 mm, a lateral resolution of 114 μm, and an axial resolution of 57 μm. We have demonstrated the 3D PACT’s performance on in vitro phantoms, ex vivo mouse brain, and in vivo mouse ear and tadpole. The MRR-based 3D-PACT system can be a promising tool for structural, functional, and molecular imaging of biological tissues at depths. |
| first_indexed | 2024-03-07T18:37:48Z |
| format | Article |
| id | doaj.art-e27267953e464866ac62426593b7adad |
| institution | Directory Open Access Journal |
| issn | 2765-8031 |
| language | English |
| last_indexed | 2024-03-07T18:37:48Z |
| publishDate | 2022-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | BME Frontiers |
| spelling | doaj.art-e27267953e464866ac62426593b7adad2024-03-02T04:46:56ZengAmerican Association for the Advancement of Science (AAAS)BME Frontiers2765-80312022-01-01202210.34133/2022/9891510High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring ResonatorQiangzhou Rong0Youngseop Lee1Yuqi Tang2Tri Vu3Carlos Taboada4Wenhan Zheng5Jun Xia6David A. Czaplewski7Hao F. Zhang8Cheng Sun9Junjie Yao10Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USADepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USADepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USADepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USADepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USAOptical & Ultrasonic Imaging Laboratory, University at Buffalo, North Campus Buffalo, NY 14260, USAOptical & Ultrasonic Imaging Laboratory, University at Buffalo, North Campus Buffalo, NY 14260, USACenter for Nanoscale Materials, Argonne National Laboratory, Argonne, IL 60439, USADepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USADepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USADepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. The development of 3D-PACT requires high-performance acoustic sensors with a small size, large detection bandwidth, and high sensitivity. In this work, we present a new high-frequency 3D-PACT system that uses a microring resonator (MRR) as the acoustic sensor. The MRR sensor has a size of 80 μm in diameter and was fabricated using the nanoimprint lithography technology. Using the MRR sensor, we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of ~23 MHz, an imaging depth of ~8 mm, a lateral resolution of 114 μm, and an axial resolution of 57 μm. We have demonstrated the 3D PACT’s performance on in vitro phantoms, ex vivo mouse brain, and in vivo mouse ear and tadpole. The MRR-based 3D-PACT system can be a promising tool for structural, functional, and molecular imaging of biological tissues at depths.http://dx.doi.org/10.34133/2022/9891510 |
| spellingShingle | Qiangzhou Rong Youngseop Lee Yuqi Tang Tri Vu Carlos Taboada Wenhan Zheng Jun Xia David A. Czaplewski Hao F. Zhang Cheng Sun Junjie Yao High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator BME Frontiers |
| title | High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator |
| title_full | High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator |
| title_fullStr | High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator |
| title_full_unstemmed | High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator |
| title_short | High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator |
| title_sort | high frequency 3d photoacoustic computed tomography using an optical microring resonator |
| url | http://dx.doi.org/10.34133/2022/9891510 |
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