The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells
Summary: The cerebellum contributes to goal-directed navigation abilities and place coding in the hippocampus. Here we investigated its contribution to foraging strategies. We recorded hippocampal neurons in mice with impaired PKC-dependent cerebellar functions (L7-PKCI) and in their littermate cont...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223002778 |
| _version_ | 1811160188469641216 |
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| author | Lu Zhang Julien Fournier Mehdi Fallahnezhad Anne-Lise Paradis Christelle Rochefort Laure Rondi-Reig |
| author_facet | Lu Zhang Julien Fournier Mehdi Fallahnezhad Anne-Lise Paradis Christelle Rochefort Laure Rondi-Reig |
| author_sort | Lu Zhang |
| collection | DOAJ |
| description | Summary: The cerebellum contributes to goal-directed navigation abilities and place coding in the hippocampus. Here we investigated its contribution to foraging strategies. We recorded hippocampal neurons in mice with impaired PKC-dependent cerebellar functions (L7-PKCI) and in their littermate controls while they performed a task where they were rewarded for visiting a subset of hidden locations. We found that L7-PKCI and control mice developed different foraging strategies: while control mice repeated spatial sequences to maximize their rewards, L7-PKCI mice persisted to use a random foraging strategy. Sequential foraging was associated with more place cells exhibiting theta-phase precession and theta rate modulation. Recording in the dark showed that PKC-dependent cerebellar functions controlled how self-motion cues contribute to the selectivity of place cells to both position and direction. Thus, the cerebellum contributes to the development of optimal sequential paths during foraging, possibly by controlling how self-motion and theta signals contribute to place cell coding. |
| first_indexed | 2024-04-10T05:53:22Z |
| format | Article |
| id | doaj.art-e2762d5442a242fda377ca0cf6c44e96 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-10T05:53:22Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-e2762d5442a242fda377ca0cf6c44e962023-03-04T04:23:39ZengElsevieriScience2589-00422023-03-01263106200The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cellsLu Zhang0Julien Fournier1Mehdi Fallahnezhad2Anne-Lise Paradis3Christelle Rochefort4Laure Rondi-Reig5Neuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, FranceNeuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, France; Corresponding authorNeuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, FranceNeuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, FranceNeuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, France; Corresponding authorNeuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, France; Corresponding authorSummary: The cerebellum contributes to goal-directed navigation abilities and place coding in the hippocampus. Here we investigated its contribution to foraging strategies. We recorded hippocampal neurons in mice with impaired PKC-dependent cerebellar functions (L7-PKCI) and in their littermate controls while they performed a task where they were rewarded for visiting a subset of hidden locations. We found that L7-PKCI and control mice developed different foraging strategies: while control mice repeated spatial sequences to maximize their rewards, L7-PKCI mice persisted to use a random foraging strategy. Sequential foraging was associated with more place cells exhibiting theta-phase precession and theta rate modulation. Recording in the dark showed that PKC-dependent cerebellar functions controlled how self-motion cues contribute to the selectivity of place cells to both position and direction. Thus, the cerebellum contributes to the development of optimal sequential paths during foraging, possibly by controlling how self-motion and theta signals contribute to place cell coding.http://www.sciencedirect.com/science/article/pii/S2589004223002778Biological sciencesNeuroscienceBehavioral neuroscience |
| spellingShingle | Lu Zhang Julien Fournier Mehdi Fallahnezhad Anne-Lise Paradis Christelle Rochefort Laure Rondi-Reig The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells iScience Biological sciences Neuroscience Behavioral neuroscience |
| title | The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells |
| title_full | The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells |
| title_fullStr | The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells |
| title_full_unstemmed | The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells |
| title_short | The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells |
| title_sort | cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells |
| topic | Biological sciences Neuroscience Behavioral neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223002778 |
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