Association of Peripheral Blood Cell Profile With Alzheimer's Disease: A Meta-Analysis
BackgroundInflammation and immune dysfunction play significant roles in the pathogenesis of Alzheimer's disease (AD)-related dementia. Changes in peripheral blood cell profiles are a common manifestation of inflammation and immune dysfunction and have been reported in patients with AD or mild c...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.888946/full |
| _version_ | 1828824931776856064 |
|---|---|
| author | Le-Tian Huang Cheng-Pu Zhang Yi-Bing Wang Jia-He Wang |
| author_facet | Le-Tian Huang Cheng-Pu Zhang Yi-Bing Wang Jia-He Wang |
| author_sort | Le-Tian Huang |
| collection | DOAJ |
| description | BackgroundInflammation and immune dysfunction play significant roles in the pathogenesis of Alzheimer's disease (AD)-related dementia. Changes in peripheral blood cell profiles are a common manifestation of inflammation and immune dysfunction and have been reported in patients with AD or mild cognitive impairment (MCI). We systematically evaluated the association of peripheral blood cell counts and indices with AD or MCI through a meta-analysis.MethodsWe electronically searched sources to identify all case–control trials comparing peripheral blood cell counts and/or lymphocyte subsets between patients with AD or MCI and healthy controls (HCs). Meta-analyses were used to estimate the between-group standardized mean difference (SMD) and 95% confidence interval (CI).ResultsA total of 36 studies involving 2,339 AD patients, 608 MCI patients, and 8,352 HCs were included. AD patients had significantly decreased lymphocyte counts (SMD −0.345, 95% CI [−0.545, −0.146], P = 0.001) and significantly increased leukocyte counts (0.140 [0.039, 0.241], P = 0.006), neutrophil counts (0.309 [0.185, 0.434], P = 0.01), and neutrophil–lymphocyte ratio (NLR) (0.644 [0.310, 0.978], P < 0.001) compared to HCs. Similarly, significantly increased leukocyte counts (0.392 [0.206, 0.579], P < 0.001), NLR (0.579 [0.310, 0.847], P < 0.001), and neutrophil counts (0.248 [0.121, 0.376], P < 0.001) were found in MCI patients compared with HCs. A significantly decreased percentage of B lymphocytes (−1.511 [−2.775, −0.248], P = 0.019) and CD8+ T cells (−0.760 [−1.460, −0.061], P = 0.033) and a significantly increased CD4/CD8 ratio (0.615 [0.074, 1.156], P = 0.026) were observed in AD patients compared to HCs. Furthermore, significant changes in hemoglobin level and platelet distribution width were found in patients with AD or MCI compared with HCs. However, no significant difference was found between AD or MCI patients and HCs in terms of platelet counts, mean corpuscular volume, red cell distribution width, mean platelet volume, and CD4+ T, CD3+ T, or natural killer cell counts.ConclusionChanges in peripheral blood cell profiles, particularly involving leukocyte, lymphocyte, neutrophil, and CD8+ T cell counts, as well as the NLR and the CD4/CD8 ratio, are closely associated with AD. The diagnostic relevance of these profiles should be investigated in future. |
| first_indexed | 2024-12-12T14:07:41Z |
| format | Article |
| id | doaj.art-e277639e02c641e382bb51a3aa391273 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T14:07:41Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-e277639e02c641e382bb51a3aa3912732022-12-22T00:22:11ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-05-011410.3389/fnagi.2022.888946888946Association of Peripheral Blood Cell Profile With Alzheimer's Disease: A Meta-AnalysisLe-Tian Huang0Cheng-Pu Zhang1Yi-Bing Wang2Jia-He Wang3Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Urology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaBackgroundInflammation and immune dysfunction play significant roles in the pathogenesis of Alzheimer's disease (AD)-related dementia. Changes in peripheral blood cell profiles are a common manifestation of inflammation and immune dysfunction and have been reported in patients with AD or mild cognitive impairment (MCI). We systematically evaluated the association of peripheral blood cell counts and indices with AD or MCI through a meta-analysis.MethodsWe electronically searched sources to identify all case–control trials comparing peripheral blood cell counts and/or lymphocyte subsets between patients with AD or MCI and healthy controls (HCs). Meta-analyses were used to estimate the between-group standardized mean difference (SMD) and 95% confidence interval (CI).ResultsA total of 36 studies involving 2,339 AD patients, 608 MCI patients, and 8,352 HCs were included. AD patients had significantly decreased lymphocyte counts (SMD −0.345, 95% CI [−0.545, −0.146], P = 0.001) and significantly increased leukocyte counts (0.140 [0.039, 0.241], P = 0.006), neutrophil counts (0.309 [0.185, 0.434], P = 0.01), and neutrophil–lymphocyte ratio (NLR) (0.644 [0.310, 0.978], P < 0.001) compared to HCs. Similarly, significantly increased leukocyte counts (0.392 [0.206, 0.579], P < 0.001), NLR (0.579 [0.310, 0.847], P < 0.001), and neutrophil counts (0.248 [0.121, 0.376], P < 0.001) were found in MCI patients compared with HCs. A significantly decreased percentage of B lymphocytes (−1.511 [−2.775, −0.248], P = 0.019) and CD8+ T cells (−0.760 [−1.460, −0.061], P = 0.033) and a significantly increased CD4/CD8 ratio (0.615 [0.074, 1.156], P = 0.026) were observed in AD patients compared to HCs. Furthermore, significant changes in hemoglobin level and platelet distribution width were found in patients with AD or MCI compared with HCs. However, no significant difference was found between AD or MCI patients and HCs in terms of platelet counts, mean corpuscular volume, red cell distribution width, mean platelet volume, and CD4+ T, CD3+ T, or natural killer cell counts.ConclusionChanges in peripheral blood cell profiles, particularly involving leukocyte, lymphocyte, neutrophil, and CD8+ T cell counts, as well as the NLR and the CD4/CD8 ratio, are closely associated with AD. The diagnostic relevance of these profiles should be investigated in future.https://www.frontiersin.org/articles/10.3389/fnagi.2022.888946/fullAlzheimer's diseaselymphocyte subsetsmeta-analysismild cognitive impairmentperipheral blood |
| spellingShingle | Le-Tian Huang Cheng-Pu Zhang Yi-Bing Wang Jia-He Wang Association of Peripheral Blood Cell Profile With Alzheimer's Disease: A Meta-Analysis Frontiers in Aging Neuroscience Alzheimer's disease lymphocyte subsets meta-analysis mild cognitive impairment peripheral blood |
| title | Association of Peripheral Blood Cell Profile With Alzheimer's Disease: A Meta-Analysis |
| title_full | Association of Peripheral Blood Cell Profile With Alzheimer's Disease: A Meta-Analysis |
| title_fullStr | Association of Peripheral Blood Cell Profile With Alzheimer's Disease: A Meta-Analysis |
| title_full_unstemmed | Association of Peripheral Blood Cell Profile With Alzheimer's Disease: A Meta-Analysis |
| title_short | Association of Peripheral Blood Cell Profile With Alzheimer's Disease: A Meta-Analysis |
| title_sort | association of peripheral blood cell profile with alzheimer s disease a meta analysis |
| topic | Alzheimer's disease lymphocyte subsets meta-analysis mild cognitive impairment peripheral blood |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.888946/full |
| work_keys_str_mv | AT letianhuang associationofperipheralbloodcellprofilewithalzheimersdiseaseametaanalysis AT chengpuzhang associationofperipheralbloodcellprofilewithalzheimersdiseaseametaanalysis AT yibingwang associationofperipheralbloodcellprofilewithalzheimersdiseaseametaanalysis AT jiahewang associationofperipheralbloodcellprofilewithalzheimersdiseaseametaanalysis |