Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices
Paper-based microfluidic devices have advanced significantly in recent years as they are affordable, automated with capillary action, portable, and biodegradable diagnostic platforms for a variety of health, environmental, and food quality applications. In terms of commercialization, however, paper-...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/16/2869 |
| _version_ | 1818850496807436288 |
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| author | Hosub Lim Ali Turab Jafry Jinkee Lee |
| author_facet | Hosub Lim Ali Turab Jafry Jinkee Lee |
| author_sort | Hosub Lim |
| collection | DOAJ |
| description | Paper-based microfluidic devices have advanced significantly in recent years as they are affordable, automated with capillary action, portable, and biodegradable diagnostic platforms for a variety of health, environmental, and food quality applications. In terms of commercialization, however, paper-based microfluidics still have to overcome significant challenges to become an authentic point-of-care testing format with the advanced capabilities of analyte purification, multiplex analysis, quantification, and detection with high sensitivity and selectivity. Moreover, fluid flow manipulation for multistep integration, which involves valving and flow velocity control, is also a critical parameter to achieve high-performance devices. Considering these limitations, the aim of this review is to (i) comprehensively analyze the fabrication techniques of microfluidic paper-based analytical devices, (ii) provide a theoretical background and various methods for fluid flow manipulation, and (iii) highlight the recent detection techniques developed for various applications, including their advantages and disadvantages. |
| first_indexed | 2024-12-19T06:50:04Z |
| format | Article |
| id | doaj.art-e2781e4892f54a9c87846c0180f613f6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-19T06:50:04Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e2781e4892f54a9c87846c0180f613f62022-12-21T20:31:46ZengMDPI AGMolecules1420-30492019-08-012416286910.3390/molecules24162869molecules24162869Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical DevicesHosub Lim0Ali Turab Jafry1Jinkee Lee2School of Mechanical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, KoreaFaculty of Mechanical Engineering, Ghulam Ishaq Khan Institute of Engineering Sciences and Technology, Topi 23640, PakistanSchool of Mechanical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, KoreaPaper-based microfluidic devices have advanced significantly in recent years as they are affordable, automated with capillary action, portable, and biodegradable diagnostic platforms for a variety of health, environmental, and food quality applications. In terms of commercialization, however, paper-based microfluidics still have to overcome significant challenges to become an authentic point-of-care testing format with the advanced capabilities of analyte purification, multiplex analysis, quantification, and detection with high sensitivity and selectivity. Moreover, fluid flow manipulation for multistep integration, which involves valving and flow velocity control, is also a critical parameter to achieve high-performance devices. Considering these limitations, the aim of this review is to (i) comprehensively analyze the fabrication techniques of microfluidic paper-based analytical devices, (ii) provide a theoretical background and various methods for fluid flow manipulation, and (iii) highlight the recent detection techniques developed for various applications, including their advantages and disadvantages.https://www.mdpi.com/1420-3049/24/16/2869microfluidicsµPAD2D µPADs3D µPADsfabricationpaper-based analytical device |
| spellingShingle | Hosub Lim Ali Turab Jafry Jinkee Lee Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices Molecules microfluidics µPAD 2D µPADs 3D µPADs fabrication paper-based analytical device |
| title | Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices |
| title_full | Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices |
| title_fullStr | Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices |
| title_full_unstemmed | Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices |
| title_short | Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices |
| title_sort | fabrication flow control and applications of microfluidic paper based analytical devices |
| topic | microfluidics µPAD 2D µPADs 3D µPADs fabrication paper-based analytical device |
| url | https://www.mdpi.com/1420-3049/24/16/2869 |
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