Case report: Sevelamer-associated colitis—a cause of pseudotumor formation with colon perforation and life-threatening bleeding

Case report: Sevelamer-associated colitis—a cause of pseudotumor formation with colon perforation and life-threatening bleeding

Chronic kidney disease (CKD) is a very common chronic non-communicable disease. Phosphate and calcium metabolism disorders are one of the most common features of CKD. Sevelamer carbonate is the most widely used non-calcium phosphate binder. Gastrointestinal (GI) injury associated with sevelamer use...

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Bibliographic Details
Main Authors: Margareta Fistrek Prlic, Mislav Jelakovic, Marko Brinar, Dora Grgic, Ivan Romic, Zlatko Marusic, Ema Ivandic, Bojan Jelakovic, Ivana Vukovic Brinar, Zeljko Krznaric
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Medicine
Subjects:
gastrointestinal lesion
gastrointestinal bleeding
colon rupture
chronic kidney disease
sevelamer carbonate
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1097469/full
Description
Summary:Chronic kidney disease (CKD) is a very common chronic non-communicable disease. Phosphate and calcium metabolism disorders are one of the most common features of CKD. Sevelamer carbonate is the most widely used non-calcium phosphate binder. Gastrointestinal (GI) injury associated with sevelamer use is a documented adverse effect but is underrecognized as a cause of gastrointestinal symptoms in patients with CKD. We report a case of a 74-year-old woman taking low-dose sevelamer with serious gastrointestinal adverse effects causing colon rupture and severe gastrointestinal bleeding.
ISSN:2296-858X

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