The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future
Due to their large geographic distribution and potential high mortality rates in human infections, hantaviruses constitute a worldwide threat to public health. As such, they have been the subject of a large array of clinical, virological and eco-evolutionary studies. Many experiments have been condu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-07-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/11/7/664 |
| _version_ | 1811192847236333568 |
|---|---|
| author | Sarah Madrières Guillaume Castel Séverine Murri Johann Vulin Philippe Marianneau Nathalie Charbonnel |
| author_facet | Sarah Madrières Guillaume Castel Séverine Murri Johann Vulin Philippe Marianneau Nathalie Charbonnel |
| author_sort | Sarah Madrières |
| collection | DOAJ |
| description | Due to their large geographic distribution and potential high mortality rates in human infections, hantaviruses constitute a worldwide threat to public health. As such, they have been the subject of a large array of clinical, virological and eco-evolutionary studies. Many experiments have been conducted in vitro or on animal models to identify the mechanisms leading to pathogenesis in humans and to develop treatments of hantavirus diseases. Experimental research has also been dedicated to the understanding of the relationship between hantaviruses and their reservoirs. However, these studies remain too scarce considering the diversity of hantavirus/reservoir pairs identified, and the wide range of issues that need to be addressed. In this review, we present a synthesis of the experimental studies that have been conducted on hantaviruses and their reservoirs. We aim at summarizing the knowledge gathered from this research, and to emphasize the gaps that need to be filled. Despite the many difficulties encountered to carry hantavirus experiments, we advocate for the need of such studies in the future, at the interface of evolutionary ecology and virology. They are critical to address emerging areas of research, including hantavirus evolution and the epidemiological consequences of individual variation in infection outcomes. |
| first_indexed | 2024-04-11T23:58:56Z |
| format | Article |
| id | doaj.art-e27c46f3e24e4299a482e173ec02c097 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-11T23:58:56Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-e27c46f3e24e4299a482e173ec02c0972022-12-22T03:56:17ZengMDPI AGViruses1999-49152019-07-0111766410.3390/v11070664v11070664The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the FutureSarah Madrières0Guillaume Castel1Séverine Murri2Johann Vulin3Philippe Marianneau4Nathalie Charbonnel5Agence Nationale de Sécurité Sanitaire de L’alimentation, de L’environnement et du Travail, Laboratoire de Lyon, Unite Virologie, 69007 Lyon, FranceCentre de Biologie Pour la Gestion des Populations (CBGP), INRA, CIRAD, IRD, Montpellier SupAgro, Univ. Montpellier, 34000 Montpellier, FranceAgence Nationale de Sécurité Sanitaire de L’alimentation, de L’environnement et du Travail, Laboratoire de Lyon, Unite Virologie, 69007 Lyon, FranceAgence Nationale de Sécurité Sanitaire de L’alimentation, de L’environnement et du Travail, Laboratoire de Lyon, Unite Virologie, 69007 Lyon, FranceAgence Nationale de Sécurité Sanitaire de L’alimentation, de L’environnement et du Travail, Laboratoire de Lyon, Unite Virologie, 69007 Lyon, FranceCentre de Biologie Pour la Gestion des Populations (CBGP), INRA, CIRAD, IRD, Montpellier SupAgro, Univ. Montpellier, 34000 Montpellier, FranceDue to their large geographic distribution and potential high mortality rates in human infections, hantaviruses constitute a worldwide threat to public health. As such, they have been the subject of a large array of clinical, virological and eco-evolutionary studies. Many experiments have been conducted in vitro or on animal models to identify the mechanisms leading to pathogenesis in humans and to develop treatments of hantavirus diseases. Experimental research has also been dedicated to the understanding of the relationship between hantaviruses and their reservoirs. However, these studies remain too scarce considering the diversity of hantavirus/reservoir pairs identified, and the wide range of issues that need to be addressed. In this review, we present a synthesis of the experimental studies that have been conducted on hantaviruses and their reservoirs. We aim at summarizing the knowledge gathered from this research, and to emphasize the gaps that need to be filled. Despite the many difficulties encountered to carry hantavirus experiments, we advocate for the need of such studies in the future, at the interface of evolutionary ecology and virology. They are critical to address emerging areas of research, including hantavirus evolution and the epidemiological consequences of individual variation in infection outcomes.https://www.mdpi.com/1999-4915/11/7/664hantavirusexperimentationsreservoirstransmissionspill-overpersistenceimmunitysuper-spreaderevolutionary ecologyvirology |
| spellingShingle | Sarah Madrières Guillaume Castel Séverine Murri Johann Vulin Philippe Marianneau Nathalie Charbonnel The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future Viruses hantavirus experimentations reservoirs transmission spill-over persistence immunity super-spreader evolutionary ecology virology |
| title | The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future |
| title_full | The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future |
| title_fullStr | The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future |
| title_full_unstemmed | The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future |
| title_short | The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future |
| title_sort | needs for developing experiments on reservoirs in hantavirus research accomplishments challenges and promises for the future |
| topic | hantavirus experimentations reservoirs transmission spill-over persistence immunity super-spreader evolutionary ecology virology |
| url | https://www.mdpi.com/1999-4915/11/7/664 |
| work_keys_str_mv | AT sarahmadrieres theneedsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT guillaumecastel theneedsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT severinemurri theneedsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT johannvulin theneedsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT philippemarianneau theneedsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT nathaliecharbonnel theneedsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT sarahmadrieres needsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT guillaumecastel needsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT severinemurri needsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT johannvulin needsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT philippemarianneau needsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture AT nathaliecharbonnel needsfordevelopingexperimentsonreservoirsinhantavirusresearchaccomplishmentschallengesandpromisesforthefuture |