Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression
Abstract The course of REM sleep behavior disorder (RBD) variates in the early stage of Parkinson’s disease. We aimed to delineate the association between the evolution pattern of probable RBD (pRBD) and the progression of Parkinson’s disease (PD). 281 de novo PD patients from the Parkinson’s Progre...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
|
| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-022-00303-0 |
| _version_ | 1797424792322703360 |
|---|---|
| author | Guanyu Ye Xiaomeng Xu Liche Zhou Aonan Zhao Lin Zhu Jun Liu |
| author_facet | Guanyu Ye Xiaomeng Xu Liche Zhou Aonan Zhao Lin Zhu Jun Liu |
| author_sort | Guanyu Ye |
| collection | DOAJ |
| description | Abstract The course of REM sleep behavior disorder (RBD) variates in the early stage of Parkinson’s disease. We aimed to delineate the association between the evolution pattern of probable RBD (pRBD) and the progression of Parkinson’s disease (PD). 281 de novo PD patients from the Parkinson’s Progression Markers Initiative database were included. Patients were followed up for a mean of 6.8 years and were classified into different groups according to the evolution patterns of pRBD. Disease progression was compared among groups using survival analysis, where the endpoint was defined as progression to Hoehn-Yahr stage 3 or higher for motor progression and progression to mild cognitive impairment for cognitive decline. At the 4th year of follow-up, four types of pRBD evolution patterns were identified: (1) non-RBD-stable (55.5%): patients persistently free of pRBD; (2) late-RBD (12.1%): patients developed pRBD during follow-up; (3) RBD-stable (24.9%): patients showed persistent pRBD, and (4) RBD-reversion (7.5%): patients showed pRBD at baseline which disappeared during follow-up. The RBD-reversion type showed the fastest motor progression while the RBD-stable type showed the fastest cognitive decline. At baseline, the RBD-reversion type showed the most severe gray matter atrophy in the middle frontal gyrus, while the RBD-stable type showed gray matter atrophy mainly in the para-hippocampal gyrus. Four types of early pRBD evolution patterns featured different brain lesions and predicted different courses of motor and cognitive decline in PD. |
| first_indexed | 2024-03-09T08:06:59Z |
| format | Article |
| id | doaj.art-e27da12641bd46c794f7cd48e7fc48d2 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-09T08:06:59Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-e27da12641bd46c794f7cd48e7fc48d22023-12-02T23:50:44ZengNature Portfolionpj Parkinson's Disease2373-80572022-04-01811810.1038/s41531-022-00303-0Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progressionGuanyu Ye0Xiaomeng Xu1Liche Zhou2Aonan Zhao3Lin Zhu4Jun Liu5Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineAbstract The course of REM sleep behavior disorder (RBD) variates in the early stage of Parkinson’s disease. We aimed to delineate the association between the evolution pattern of probable RBD (pRBD) and the progression of Parkinson’s disease (PD). 281 de novo PD patients from the Parkinson’s Progression Markers Initiative database were included. Patients were followed up for a mean of 6.8 years and were classified into different groups according to the evolution patterns of pRBD. Disease progression was compared among groups using survival analysis, where the endpoint was defined as progression to Hoehn-Yahr stage 3 or higher for motor progression and progression to mild cognitive impairment for cognitive decline. At the 4th year of follow-up, four types of pRBD evolution patterns were identified: (1) non-RBD-stable (55.5%): patients persistently free of pRBD; (2) late-RBD (12.1%): patients developed pRBD during follow-up; (3) RBD-stable (24.9%): patients showed persistent pRBD, and (4) RBD-reversion (7.5%): patients showed pRBD at baseline which disappeared during follow-up. The RBD-reversion type showed the fastest motor progression while the RBD-stable type showed the fastest cognitive decline. At baseline, the RBD-reversion type showed the most severe gray matter atrophy in the middle frontal gyrus, while the RBD-stable type showed gray matter atrophy mainly in the para-hippocampal gyrus. Four types of early pRBD evolution patterns featured different brain lesions and predicted different courses of motor and cognitive decline in PD.https://doi.org/10.1038/s41531-022-00303-0 |
| spellingShingle | Guanyu Ye Xiaomeng Xu Liche Zhou Aonan Zhao Lin Zhu Jun Liu Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression npj Parkinson's Disease |
| title | Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression |
| title_full | Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression |
| title_fullStr | Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression |
| title_full_unstemmed | Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression |
| title_short | Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression |
| title_sort | evolution patterns of probable rem sleep behavior disorder predicts parkinson s disease progression |
| url | https://doi.org/10.1038/s41531-022-00303-0 |
| work_keys_str_mv | AT guanyuye evolutionpatternsofprobableremsleepbehaviordisorderpredictsparkinsonsdiseaseprogression AT xiaomengxu evolutionpatternsofprobableremsleepbehaviordisorderpredictsparkinsonsdiseaseprogression AT lichezhou evolutionpatternsofprobableremsleepbehaviordisorderpredictsparkinsonsdiseaseprogression AT aonanzhao evolutionpatternsofprobableremsleepbehaviordisorderpredictsparkinsonsdiseaseprogression AT linzhu evolutionpatternsofprobableremsleepbehaviordisorderpredictsparkinsonsdiseaseprogression AT junliu evolutionpatternsofprobableremsleepbehaviordisorderpredictsparkinsonsdiseaseprogression |