Integrated Lipidomics and Metabolomics Study of Four Chemically Induced Mouse Models of Acute Intrahepatic Cholestasis

Integrated Lipidomics and Metabolomics Study of Four Chemically Induced Mouse Models of Acute Intrahepatic Cholestasis

Lithocholic acid (LCA), alpha-naphthyl isothiocyanate (ANIT), 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), and ethinyl estradiol (EE) are four commonly used chemicals for the construction of acute intrahepatic cholestasis. In order to better understand the mechanisms of acute cholestasis caused...

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Bibliographic Details
Main Authors: Weiwei Li, Hui Chen, Yihan Qian, Shouchuan Wang, Zichen Luo, Jinjun Shan, Xiaoni Kong, Yueqiu Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
lipidomics
metabolomics
acute intrahepatic cholestasis
mouse model
LC-MS
GC-MS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.907271/full

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