Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy

Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy

Patients with malignant tumors frequently suffer during disease progression from a syndrome referred to as cancer cachexia (CaCax): CaCax includes skeletal muscle atrophy and weakness, loss of bodyweight, and fat tissues. Currently, there are no FDA (Food and Drug Administration) approved treatments...

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Bibliographic Details
Main Authors:	Volker Adams, Victoria Gußen, Sergey Zozulya, André Cruz, Anselmo Moriscot, Axel Linke, Siegfried Labeit
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	Cells
Subjects:	cancer cachexia melanoma tumors muscle wasting mitochondrial metabolism MuRF1 chemical biology
Online Access:	https://www.mdpi.com/2073-4409/9/10/2272

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