Hepatocyte-specific Sox9 knockout ameliorates acute liver injury by suppressing SHP signaling and improving mitochondrial function

Hepatocyte-specific Sox9 knockout ameliorates acute liver injury by suppressing SHP signaling and improving mitochondrial function

Abstract Background and Aims Sex determining region Y related high-mobility group box protein 9 (Sox9) is expressed in a subset of hepatocytes, and it is important for chronic liver injury. However, the roles of Sox9+ hepatocytes in response to the acute liver injury and repair are poorly understood...

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Bibliographic Details
Main Authors: Dan Qin, Rui Wang, Jinwei Ji, Duo Wang, Yuanyuan Lu, Shiyao Cao, Yaqing Chen, Liqiang Wang, Xiangmei Chen, Lisheng Zhang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cell & Bioscience
Subjects:
Sox9
Acute liver injury
Hepatocyte
SHP
Mitochondria
Online Access:https://doi.org/10.1186/s13578-023-01104-5

Internet

https://doi.org/10.1186/s13578-023-01104-5

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