Intracranial Activity of Osimertinib Plus Capmatinib in a Patient With EGFR and MET-Driven Lung Cancer: Case Report
We previously published in the Journal of Thoracic Oncology the case of a patient with EGFR and MET-driven lung cancer and extracranial response to capmatinib and osimertinib. Here, we report on a second patient treated with the same combination, revealing complete and durable intracranial response....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | JTO Clinical and Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666364321000217 |
| _version_ | 1819292748395577344 |
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| author | Oliver Gautschi, MD Joachim Diebold, MD |
| author_facet | Oliver Gautschi, MD Joachim Diebold, MD |
| author_sort | Oliver Gautschi, MD |
| collection | DOAJ |
| description | We previously published in the Journal of Thoracic Oncology the case of a patient with EGFR and MET-driven lung cancer and extracranial response to capmatinib and osimertinib. Here, we report on a second patient treated with the same combination, revealing complete and durable intracranial response. Adding capmatinib to osimertinib seems to be an effective salvage therapy for patients with EGFR-mutant lung cancer and acquired MET amplification. |
| first_indexed | 2024-12-24T03:59:28Z |
| format | Article |
| id | doaj.art-e280c49bd11e4b0c9121680ef34768c7 |
| institution | Directory Open Access Journal |
| issn | 2666-3643 |
| language | English |
| last_indexed | 2024-12-24T03:59:28Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTO Clinical and Research Reports |
| spelling | doaj.art-e280c49bd11e4b0c9121680ef34768c72022-12-21T17:16:22ZengElsevierJTO Clinical and Research Reports2666-36432021-04-0124100162Intracranial Activity of Osimertinib Plus Capmatinib in a Patient With EGFR and MET-Driven Lung Cancer: Case ReportOliver Gautschi, MD0Joachim Diebold, MD1Corresponding author. Address for correspondence: Oliver Gautschi, MD, Department of Oncology, Cantonal Hospital Lucerne, Lucerne, Switzerland.; Cantonal Hospital Lucerne, Cancer Center, Lucerne, SwitzerlandCantonal Hospital Lucerne, Cancer Center, Lucerne, SwitzerlandWe previously published in the Journal of Thoracic Oncology the case of a patient with EGFR and MET-driven lung cancer and extracranial response to capmatinib and osimertinib. Here, we report on a second patient treated with the same combination, revealing complete and durable intracranial response. Adding capmatinib to osimertinib seems to be an effective salvage therapy for patients with EGFR-mutant lung cancer and acquired MET amplification.http://www.sciencedirect.com/science/article/pii/S2666364321000217Lung cancerTargeted therapyCapmatinibOsimertinibCase report |
| spellingShingle | Oliver Gautschi, MD Joachim Diebold, MD Intracranial Activity of Osimertinib Plus Capmatinib in a Patient With EGFR and MET-Driven Lung Cancer: Case Report JTO Clinical and Research Reports Lung cancer Targeted therapy Capmatinib Osimertinib Case report |
| title | Intracranial Activity of Osimertinib Plus Capmatinib in a Patient With EGFR and MET-Driven Lung Cancer: Case Report |
| title_full | Intracranial Activity of Osimertinib Plus Capmatinib in a Patient With EGFR and MET-Driven Lung Cancer: Case Report |
| title_fullStr | Intracranial Activity of Osimertinib Plus Capmatinib in a Patient With EGFR and MET-Driven Lung Cancer: Case Report |
| title_full_unstemmed | Intracranial Activity of Osimertinib Plus Capmatinib in a Patient With EGFR and MET-Driven Lung Cancer: Case Report |
| title_short | Intracranial Activity of Osimertinib Plus Capmatinib in a Patient With EGFR and MET-Driven Lung Cancer: Case Report |
| title_sort | intracranial activity of osimertinib plus capmatinib in a patient with egfr and met driven lung cancer case report |
| topic | Lung cancer Targeted therapy Capmatinib Osimertinib Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2666364321000217 |
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