Infliximab and Plant-Based Diet as First-Line Therapy Followed by Corticosteroid Therapy for Severe Ulcerative Colitis: A Case Report
We developed infliximab and a plant-based diet as first-line (IPF) therapies for severe ulcerative colitis (UC). It increased the remission rate and decreased the colectomy rate compared to those of current standards. We encountered a case with severe UC in which the consecutive use of IPF therapy a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Gastrointestinal Disorders |
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| Online Access: | https://www.mdpi.com/2624-5647/4/4/22 |
| _version_ | 1797458142755291136 |
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| author | Mitsuro Chiba Tsuyotoshi Tsuji Rie Masai Masaru Odashima Masato Sageshima |
| author_facet | Mitsuro Chiba Tsuyotoshi Tsuji Rie Masai Masaru Odashima Masato Sageshima |
| author_sort | Mitsuro Chiba |
| collection | DOAJ |
| description | We developed infliximab and a plant-based diet as first-line (IPF) therapies for severe ulcerative colitis (UC). It increased the remission rate and decreased the colectomy rate compared to those of current standards. We encountered a case with severe UC in which the consecutive use of IPF therapy and corticosteroid therapy was required to induce remission. A 21-year-old male worker developed diarrhea, abdominal pain, marked weight loss from 70 to 55 kg, and anorexia. He was diagnosed with severe ulcerative colitis. IPF therapy was initiated. Improvement in symptoms and biomarkers was seen soon after the first infusion of infliximab (300 mg). Further improvement in symptoms was observed after both the second and third infliximab infusions. Loose stool and abdominal pain on defecation were still present, however, and biomarkers were above the reference range. Therefore, oral prednisolone (40 mg/day) was consecutively initiated. This resulted in clinical and endoscopic remission. In conclusion, we present a severe UC case in which the response to IPF therapy was insufficient. Consecutive oral prednisolone successfully induced remission. This new stepwise modality will make IPF therapy the first-choice therapy for severe UC. |
| first_indexed | 2024-03-09T16:32:48Z |
| format | Article |
| id | doaj.art-e281b7c240a74f1daf8afc44e515533f |
| institution | Directory Open Access Journal |
| issn | 2624-5647 |
| language | English |
| last_indexed | 2024-03-09T16:32:48Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gastrointestinal Disorders |
| spelling | doaj.art-e281b7c240a74f1daf8afc44e515533f2023-11-24T15:00:15ZengMDPI AGGastrointestinal Disorders2624-56472022-09-014423023610.3390/gidisord4040022Infliximab and Plant-Based Diet as First-Line Therapy Followed by Corticosteroid Therapy for Severe Ulcerative Colitis: A Case ReportMitsuro Chiba0Tsuyotoshi Tsuji1Rie Masai2Masaru Odashima3Masato Sageshima4Division of Gastroenterology, Akita City Hospital, Akita 010-0933, JapanDivision of Gastroenterology, Akita City Hospital, Akita 010-0933, JapanDivision of Hematology and Nephrology, Akita City Hospital, Akita 010-0933, JapanOdashima Masaru Clinic, Yokote City 013-0061, JapanDivision of Pathology, Akita City Hospital, Akita 010-0933, JapanWe developed infliximab and a plant-based diet as first-line (IPF) therapies for severe ulcerative colitis (UC). It increased the remission rate and decreased the colectomy rate compared to those of current standards. We encountered a case with severe UC in which the consecutive use of IPF therapy and corticosteroid therapy was required to induce remission. A 21-year-old male worker developed diarrhea, abdominal pain, marked weight loss from 70 to 55 kg, and anorexia. He was diagnosed with severe ulcerative colitis. IPF therapy was initiated. Improvement in symptoms and biomarkers was seen soon after the first infusion of infliximab (300 mg). Further improvement in symptoms was observed after both the second and third infliximab infusions. Loose stool and abdominal pain on defecation were still present, however, and biomarkers were above the reference range. Therefore, oral prednisolone (40 mg/day) was consecutively initiated. This resulted in clinical and endoscopic remission. In conclusion, we present a severe UC case in which the response to IPF therapy was insufficient. Consecutive oral prednisolone successfully induced remission. This new stepwise modality will make IPF therapy the first-choice therapy for severe UC.https://www.mdpi.com/2624-5647/4/4/22infliximabplant-based dietulcerative colitisseverecase reporttherapy |
| spellingShingle | Mitsuro Chiba Tsuyotoshi Tsuji Rie Masai Masaru Odashima Masato Sageshima Infliximab and Plant-Based Diet as First-Line Therapy Followed by Corticosteroid Therapy for Severe Ulcerative Colitis: A Case Report Gastrointestinal Disorders infliximab plant-based diet ulcerative colitis severe case report therapy |
| title | Infliximab and Plant-Based Diet as First-Line Therapy Followed by Corticosteroid Therapy for Severe Ulcerative Colitis: A Case Report |
| title_full | Infliximab and Plant-Based Diet as First-Line Therapy Followed by Corticosteroid Therapy for Severe Ulcerative Colitis: A Case Report |
| title_fullStr | Infliximab and Plant-Based Diet as First-Line Therapy Followed by Corticosteroid Therapy for Severe Ulcerative Colitis: A Case Report |
| title_full_unstemmed | Infliximab and Plant-Based Diet as First-Line Therapy Followed by Corticosteroid Therapy for Severe Ulcerative Colitis: A Case Report |
| title_short | Infliximab and Plant-Based Diet as First-Line Therapy Followed by Corticosteroid Therapy for Severe Ulcerative Colitis: A Case Report |
| title_sort | infliximab and plant based diet as first line therapy followed by corticosteroid therapy for severe ulcerative colitis a case report |
| topic | infliximab plant-based diet ulcerative colitis severe case report therapy |
| url | https://www.mdpi.com/2624-5647/4/4/22 |
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