Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET

Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET

Abstract Background Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irreversible uptake may also be present, which influences quantification...

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Bibliographic Details
Main Authors: Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt, Marc C. Huisman
Format: Article
Language:English
Published: SpringerOpen 2024-02-01
Series:EJNMMI Research
Subjects:
Positron emission tomography
Monoclonal antibodies
Zirconium-89
Molecular imaging
Online Access:https://doi.org/10.1186/s13550-024-01079-5

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