Development of a new drug candidate for the inhibition of Lassa virus glycoprotein and nucleoprotein by modification of evodiamine as promising therapeutic agents

Development of a new drug candidate for the inhibition of Lassa virus glycoprotein and nucleoprotein by modification of evodiamine as promising therapeutic agents

The Lassa virus (LASV), an RNA virus prevalent in West and Central Africa, causes severe hemorrhagic fever with a high fatality rate. However, no FDA-approved treatments or vaccines exist. Two crucial proteins, LASV glycoprotein and nucleoprotein, play vital roles in pathogenesis and are potential t...

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Bibliographic Details
Main Authors: Shopnil Akash, Javiera Baeza, Sajjat Mahmood, Nobendu Mukerjee, Vetriselvan Subramaniyan, Md. Rezaul Islam, Gaurav Gupta, Vinibha Rajakumari, Suresh V. Chinni, Gobinath Ramachawolran, Fayez M. Saleh, Ghadeer M. Albadrani, Amany A. Sayed, Mohamed M. Abdel-Daim
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Microbiology
Subjects:
Lassa fever virus
emerging viral infections
drug discovery
ADMET
molecular docking
molecular dynamics simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1206872/full

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