Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino rats
The aim of this study was to investigate the ameliorative effect of Broccoli against lead acetate (PbA) hepatotoxicity by some physiological and histological indicators. The results showed that intraperitoneal (I.P.) injection by 12 mg/kg body weight of lead acetate once a week for 8 weeks led to an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2019-03-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://vetmedmosul.com/article_159479_8b9043c9c43adb63cbe3692844d9431c.pdf |
| _version_ | 1818448736220610560 |
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| author | Sulaf Mohammed Majida Noori Ibrahim Mahmood Ahmed |
| author_facet | Sulaf Mohammed Majida Noori Ibrahim Mahmood Ahmed |
| author_sort | Sulaf Mohammed |
| collection | DOAJ |
| description | The aim of this study was to investigate the ameliorative effect of Broccoli against lead acetate (PbA) hepatotoxicity by some physiological and histological indicators. The results showed that intraperitoneal (I.P.) injection by 12 mg/kg body weight of lead acetate once a week for 8 weeks led to an increase in the activity of Glutamate pyruvate transaminase (GPT), Glutamate oxaloacetate transaminase (GOT), Alkaline phosphatase (ALP), Acid phosphatase (ACP), Total serum protein (TP) and Total serum bilirubin (TSB). Liver's histological sections of lead acetate injected rats showed infiltration of inflammatory cells with sinusoid dilation, necrosis, and apoptosis of Kupffer cells. Broccoli has an ameliorative effect, that the physiological parameters and histological examination have been showed an improvement. In conclusion, lead acetate produces hepatic disorder and the potential use of Broccoli as a source of natural antioxidants or nutraceuticals protects against lead acetate hepatic toxicity. |
| first_indexed | 2024-12-14T20:24:15Z |
| format | Article |
| id | doaj.art-e2843d98927341feba44f0516872fcfd |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-12-14T20:24:15Z |
| publishDate | 2019-03-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-e2843d98927341feba44f0516872fcfd2022-12-21T22:48:39ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552019-03-01331212610.33899/ijvs.2019.125528.1050159479Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino ratsSulaf Mohammed0Majida Noori Ibrahim1Mahmood Ahmed2Biology department, College of Science, University of SulaimaniBiology department, College of Science, University of KirkukBiology department, College of Science, University of SulaimaniThe aim of this study was to investigate the ameliorative effect of Broccoli against lead acetate (PbA) hepatotoxicity by some physiological and histological indicators. The results showed that intraperitoneal (I.P.) injection by 12 mg/kg body weight of lead acetate once a week for 8 weeks led to an increase in the activity of Glutamate pyruvate transaminase (GPT), Glutamate oxaloacetate transaminase (GOT), Alkaline phosphatase (ALP), Acid phosphatase (ACP), Total serum protein (TP) and Total serum bilirubin (TSB). Liver's histological sections of lead acetate injected rats showed infiltration of inflammatory cells with sinusoid dilation, necrosis, and apoptosis of Kupffer cells. Broccoli has an ameliorative effect, that the physiological parameters and histological examination have been showed an improvement. In conclusion, lead acetate produces hepatic disorder and the potential use of Broccoli as a source of natural antioxidants or nutraceuticals protects against lead acetate hepatic toxicity.https://vetmedmosul.com/article_159479_8b9043c9c43adb63cbe3692844d9431c.pdfbroccolileadliver functionliver histologyhistopathology |
| spellingShingle | Sulaf Mohammed Majida Noori Ibrahim Mahmood Ahmed Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino rats Iraqi Journal of Veterinary Sciences broccoli lead liver function liver histology histopathology |
| title | Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino rats |
| title_full | Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino rats |
| title_fullStr | Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino rats |
| title_full_unstemmed | Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino rats |
| title_short | Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino rats |
| title_sort | physiological and histological effects of broccoli on lead acetate induced hepatotoxicity in young male albino rats |
| topic | broccoli lead liver function liver histology histopathology |
| url | https://vetmedmosul.com/article_159479_8b9043c9c43adb63cbe3692844d9431c.pdf |
| work_keys_str_mv | AT sulafmohammed physiologicalandhistologicaleffectsofbroccolionleadacetateinducedhepatotoxicityinyoungmalealbinorats AT majidanooriibrahim physiologicalandhistologicaleffectsofbroccolionleadacetateinducedhepatotoxicityinyoungmalealbinorats AT mahmoodahmed physiologicalandhistologicaleffectsofbroccolionleadacetateinducedhepatotoxicityinyoungmalealbinorats |