Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure
ObjectivesIn laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments. With such treatment, salvage surgery has increased following recurrence; the incidence of pharyngocutaneous fistula has also increased i...
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| Format: | Article |
| Language: | English |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2015-12-01
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| Series: | Clinical and Experimental Otorhinolaryngology |
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| Online Access: | http://www.e-ceo.org/upload/pdf/ceo-8-390.pdf |
| _version_ | 1819174730197893120 |
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| author | Nurten Kucuk Murat Sari Ahmet Midi Ali Cemal Yumusakhuylu Ozan Findik Adem Binnetoglu |
| author_facet | Nurten Kucuk Murat Sari Ahmet Midi Ali Cemal Yumusakhuylu Ozan Findik Adem Binnetoglu |
| author_sort | Nurten Kucuk |
| collection | DOAJ |
| description | ObjectivesIn laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments. With such treatment, salvage surgery has increased following recurrence; the incidence of pharyngocutaneous fistula has also increased in both respiratory and digestive system surgery. We investigated the effects of recombinant human growth hormone on pharyngocutaneous fistula closure in Sprague-Dawley rats, based on an increase in amino acid uptake and protein synthesis for wound healing, an increase in mitogenesis, and enhancement of collagen formation by recombinant human growth hormone.MethodsThis study was experimental animal study. Forty Sprague-Dawley rats were separated into two groups, and pharyngoesophagotomy was performed. The pharyngoesophagotomy was sutured with vicryl in both groups. Rats in group 1 (control group) received no treatment, while those in group 2 were administered a subcutaneous injection of recombinant human growth hormone daily. On day 14, the pharynx, larynx, and upper oesophagus were excised and examined microscopically.ResultsPharyngocutaneous fistula exhibited better closure macroscopically in the recombinant human growth hormone group. There was a significant difference in collagen formation and epithelisation in the recombinant human growth hormone group compared to the control group.ConclusionThis study is believed to be the first in which the effect of recombinant human growth hormone on pharyngocutaneous fistula closure was evaluated, and the findings suggest the potential of use of growth hormone for treatment of pharyngocutaneous fistula. |
| first_indexed | 2024-12-22T20:43:37Z |
| format | Article |
| id | doaj.art-e2884095b0534b5fa99902405efec629 |
| institution | Directory Open Access Journal |
| issn | 1976-8710 2005-0720 |
| language | English |
| last_indexed | 2024-12-22T20:43:37Z |
| publishDate | 2015-12-01 |
| publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
| record_format | Article |
| series | Clinical and Experimental Otorhinolaryngology |
| spelling | doaj.art-e2884095b0534b5fa99902405efec6292022-12-21T18:13:16ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202015-12-018439039510.3342/ceo.2015.8.4.390402Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula ClosureNurten Kucuk0Murat Sari1Ahmet Midi2Ali Cemal Yumusakhuylu3Ozan Findik4Adem Binnetoglu5Department of Otolaryngology-Head and Neck Surgery, Marmara University Faculty of Medicine, Istanbul, Turkey.Department of Otolaryngology-Head and Neck Surgery, Marmara University Faculty of Medicine, Istanbul, Turkey.Department of Pathology, Bahcesehir University Faculty of Medicine, Istanbul, Turkey.Department of Otolaryngology-Head and Neck Surgery, Marmara University Faculty of Medicine, Istanbul, Turkey.Department of Otolaryngology-Head and Neck Surgery, Marmara University Faculty of Medicine, Istanbul, Turkey.Department of Otolaryngology-Head and Neck Surgery, Marmara University Faculty of Medicine, Istanbul, Turkey.ObjectivesIn laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments. With such treatment, salvage surgery has increased following recurrence; the incidence of pharyngocutaneous fistula has also increased in both respiratory and digestive system surgery. We investigated the effects of recombinant human growth hormone on pharyngocutaneous fistula closure in Sprague-Dawley rats, based on an increase in amino acid uptake and protein synthesis for wound healing, an increase in mitogenesis, and enhancement of collagen formation by recombinant human growth hormone.MethodsThis study was experimental animal study. Forty Sprague-Dawley rats were separated into two groups, and pharyngoesophagotomy was performed. The pharyngoesophagotomy was sutured with vicryl in both groups. Rats in group 1 (control group) received no treatment, while those in group 2 were administered a subcutaneous injection of recombinant human growth hormone daily. On day 14, the pharynx, larynx, and upper oesophagus were excised and examined microscopically.ResultsPharyngocutaneous fistula exhibited better closure macroscopically in the recombinant human growth hormone group. There was a significant difference in collagen formation and epithelisation in the recombinant human growth hormone group compared to the control group.ConclusionThis study is believed to be the first in which the effect of recombinant human growth hormone on pharyngocutaneous fistula closure was evaluated, and the findings suggest the potential of use of growth hormone for treatment of pharyngocutaneous fistula.http://www.e-ceo.org/upload/pdf/ceo-8-390.pdfPharyngocutaneous FistulaRecombinant Human Growth HormonePostoperative Laryngectomy Complications |
| spellingShingle | Nurten Kucuk Murat Sari Ahmet Midi Ali Cemal Yumusakhuylu Ozan Findik Adem Binnetoglu Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure Clinical and Experimental Otorhinolaryngology Pharyngocutaneous Fistula Recombinant Human Growth Hormone Postoperative Laryngectomy Complications |
| title | Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure |
| title_full | Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure |
| title_fullStr | Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure |
| title_full_unstemmed | Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure |
| title_short | Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure |
| title_sort | effectiveness of recombinant human growth hormone for pharyngocutaneous fistula closure |
| topic | Pharyngocutaneous Fistula Recombinant Human Growth Hormone Postoperative Laryngectomy Complications |
| url | http://www.e-ceo.org/upload/pdf/ceo-8-390.pdf |
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