Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice
Background:Cognitive deficits and behavioral disorders such as anxiety and depression are common manifestations of Alzheimer’s disease (AD). Our previous work demonstrated that Trichostatin A (TSA) could alleviate neuroinflammatory plaques and improve cognitive disorders. AD, anxiety, and depression...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1333235/full |
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| author | Qiang Su Yu-Hua Ren Guo-Wei Liu Yan-Ping Gao Jiu-Xuan Zhang Jin-Nan Zhang Xia-Xia Pei Tian Li |
| author_facet | Qiang Su Yu-Hua Ren Guo-Wei Liu Yan-Ping Gao Jiu-Xuan Zhang Jin-Nan Zhang Xia-Xia Pei Tian Li |
| author_sort | Qiang Su |
| collection | DOAJ |
| description | Background:Cognitive deficits and behavioral disorders such as anxiety and depression are common manifestations of Alzheimer’s disease (AD). Our previous work demonstrated that Trichostatin A (TSA) could alleviate neuroinflammatory plaques and improve cognitive disorders. AD, anxiety, and depression are all associated with microglial inflammation. However, whether TSA could attenuate anxiety- and depression-like behaviors in APP/PS1 mice through anti-inflammatory signaling is still unclearly.Methods:In the present study, all mice were subjected to the open field, elevated plus maze, and forced swim tests to assess anxiety- and depression-related behaviors after TSA administration. To understand the possible mechanisms underlying the behavioral effects observed, CST7 was measured in the hippocampus of mice and LPS-treated BV2 microglia.Results:The results of this study indicated that TSA administration relieved the behaviors of depression and anxiety in APP/PS1 mice, and decreased CST7 levels in the hippocampus of APP/PS1 mice and LPS-induced BV2 cells.Conclusion:Overall, these findings support the idea that TSA might be beneficial for reducing neurobehavioral disorders in AD and this could be due to suppression of CST7-related microglial inflammation. |
| first_indexed | 2024-04-24T22:24:10Z |
| format | Article |
| id | doaj.art-e2885db653cc48f199ab791914a302a8 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-24T22:24:10Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-e2885db653cc48f199ab791914a302a82024-03-20T04:25:51ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-03-011510.3389/fphar.2024.13332351333235Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 miceQiang Su0Yu-Hua Ren1Guo-Wei Liu2Yan-Ping Gao3Jiu-Xuan Zhang4Jin-Nan Zhang5Xia-Xia Pei6Tian Li7Department of Laboratory Medicine of Fenyang College, Shanxi Medical University, Fenyang, Shanxi, ChinaDepartment of Laboratory Medicine of Fenyang College, Shanxi Medical University, Fenyang, Shanxi, ChinaDepartment of Laboratory Medicine of Fenyang College, Shanxi Medical University, Fenyang, Shanxi, ChinaDepartment of Laboratory Medicine of Fenyang College, Shanxi Medical University, Fenyang, Shanxi, ChinaDepartment of Laboratory Medicine of Fenyang College, Shanxi Medical University, Fenyang, Shanxi, ChinaDepartment of Physiology, School of Basic Medicine, Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Key Laboratory of Cell Physiology, Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Laboratory Medicine of Fenyang College, Shanxi Medical University, Fenyang, Shanxi, ChinaDepartment of Physiology, School of Basic Medicine, Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Key Laboratory of Cell Physiology, Shanxi Medical University, Taiyuan, Shanxi, ChinaBackground:Cognitive deficits and behavioral disorders such as anxiety and depression are common manifestations of Alzheimer’s disease (AD). Our previous work demonstrated that Trichostatin A (TSA) could alleviate neuroinflammatory plaques and improve cognitive disorders. AD, anxiety, and depression are all associated with microglial inflammation. However, whether TSA could attenuate anxiety- and depression-like behaviors in APP/PS1 mice through anti-inflammatory signaling is still unclearly.Methods:In the present study, all mice were subjected to the open field, elevated plus maze, and forced swim tests to assess anxiety- and depression-related behaviors after TSA administration. To understand the possible mechanisms underlying the behavioral effects observed, CST7 was measured in the hippocampus of mice and LPS-treated BV2 microglia.Results:The results of this study indicated that TSA administration relieved the behaviors of depression and anxiety in APP/PS1 mice, and decreased CST7 levels in the hippocampus of APP/PS1 mice and LPS-induced BV2 cells.Conclusion:Overall, these findings support the idea that TSA might be beneficial for reducing neurobehavioral disorders in AD and this could be due to suppression of CST7-related microglial inflammation.https://www.frontiersin.org/articles/10.3389/fphar.2024.1333235/fullTrichostatin AAlzheimer’s diseaseAPP/PS1 miceanxietydepressionCST7 |
| spellingShingle | Qiang Su Yu-Hua Ren Guo-Wei Liu Yan-Ping Gao Jiu-Xuan Zhang Jin-Nan Zhang Xia-Xia Pei Tian Li Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice Frontiers in Pharmacology Trichostatin A Alzheimer’s disease APP/PS1 mice anxiety depression CST7 |
| title | Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice |
| title_full | Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice |
| title_fullStr | Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice |
| title_full_unstemmed | Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice |
| title_short | Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice |
| title_sort | trichostatin a relieves anxiety and depression like symptoms in app ps1 mice |
| topic | Trichostatin A Alzheimer’s disease APP/PS1 mice anxiety depression CST7 |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1333235/full |
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