Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice

Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice

Background:Cognitive deficits and behavioral disorders such as anxiety and depression are common manifestations of Alzheimer’s disease (AD). Our previous work demonstrated that Trichostatin A (TSA) could alleviate neuroinflammatory plaques and improve cognitive disorders. AD, anxiety, and depression...

Full description

Bibliographic Details
Main Authors:	Qiang Su, Yu-Hua Ren, Guo-Wei Liu, Yan-Ping Gao, Jiu-Xuan Zhang, Jin-Nan Zhang, Xia-Xia Pei, Tian Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Pharmacology
Subjects:	Trichostatin A Alzheimer’s disease APP/PS1 mice anxiety depression CST7
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1333235/full

Similar Items

Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice
by: Xue Li, et al.
Published: (2023-12-01)

Examination of Longitudinal Alterations in Alzheimer’s Disease-Related Neurogenesis in an APP/PS1 Transgenic Mouse Model, and the Effects of P33, a Putative Neuroprotective Agent Thereon
by: Titanilla Szögi, et al.
Published: (2022-09-01)

Effects of Qi-Fu-Yin on aging of APP/PS1 transgenic mice by regulating the intestinal microbiome
by: Qiu-yue Xiao, et al.
Published: (2023-01-01)

Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice
by: Xuewang Li, et al.
Published: (2023-04-01)

Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation
by: Kun Cao, et al.
Published: (2019-04-01)

Pathological and Synaptic Morphological Changes of the Olfactory Bulb in APP/PS1 Model Mice at Different Ages and the Intervention Effect of Memantine
by: LIU Jiani, et al.
Published: (2022-06-01)

Acacetin improves cognitive function of APP/PS1 Alzheimer’s disease model mice via the NLRP3 inflammasome signaling pathway
by: Bu Juan, et al.
Published: (2022-10-01)

Effects of multi-mode physical stimulation on APP/PS1 Alzheimer's disease model mice
by: Shupeng Liu, et al.
Published: (2022-12-01)

Multifunctional Gomisin B enhances cognitive function in APP/PS1 transgenic mice by regulating Aβ clearance and neuronal apoptosis
by: Jinman Liu, et al.
Published: (2023-10-01)

Trichostatin A Alleviates Renal Interstitial Fibrosis Through Modulation of the M2 Macrophage Subpopulation
by: Wei-Cheng Tseng, et al.
Published: (2020-08-01)

AdipoRon induces AMPK activation and ameliorates Alzheimer's like pathologies and associated cognitive impairment in APP/PS1 mice
by: Mayuri Khandelwal, et al.
Published: (2022-11-01)

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease
by: Cátia R. Lopes, et al.
Published: (2023-04-01)

Meta-analysis of trichostatin A treatment effects on mouse somatic cell nuclear transfer
by: ZHENHUA GUO, et al.
Published: (2019-05-01)

Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice
by: Yanhong Wang, et al.
Published: (2022-03-01)

Preliminary study on early diagnosis of Alzheimer’s disease in APP/PS1 transgenic mice using multimodal magnetic resonance imaging
by: Meng Xu, et al.
Published: (2024-02-01)

Effects of 50 Hz magnetic field exposure on metabolism of cerebral cortex in APP/PS1 transgenic mice
by: ZHANG Yanwen, et al.
Published: (2023-02-01)

Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice
by: Fanchang Wu, et al.
Published: (2023-07-01)

Effects of trichostatin A on FHIT and WWOX genes expression, cell growth inhibition and apoptosis induction in hepatocellular carcinoma WCH 17 cell line
by: Masumeh Sanaei, et al.
Published: (2021-10-01)

Ginsenoside Rk3 ameliorates Aβ-induced neurotoxicity in APP/PS1 model mice via AMPK signaling pathway
by: Lingyu She, et al.
Published: (2023-02-01)

Pharmacological Properties of Trichostatin A, Focusing on the Anticancer Potential: A Comprehensive Review
by: Abdelhakim Bouyahya, et al.
Published: (2022-10-01)

Age- and sex-related differences of periodontal bone resorption, cognitive function, and immune state in APP/PS1 murine model of Alzheimer’s disease
by: Huiwen Chen, et al.
Published: (2023-06-01)

Partial Endothelial Nitric Oxide Synthase Deficiency Exacerbates Cognitive Deficit and Amyloid Pathology in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease
by: Sara Ahmed, et al.
Published: (2022-06-01)

Trichostatin D as a Novel KLF2 Activator Attenuates TNFα-Induced Endothelial Inflammation
by: Lijuan Lei, et al.
Published: (2022-11-01)

Age-Dependent Hippocampal Proteomics in the APP/PS1 Alzheimer Mouse Model: A Comparative Analysis with Classical SWATH/DIA and directDIA Approaches
by: Sophie J. F. van der Spek, et al.
Published: (2021-06-01)

Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer’s Disease
by: Oksana Fihurka, et al.
Published: (2023-01-01)

Cerebroprotein hydrolysate attenuates neurodegenerative changes in Alzheimer’s mice model via ferroptosis pathway
by: Moxi Chen, et al.
Published: (2023-04-01)

Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity
by: Katrina V. Good, et al.
Published: (2017-11-01)

The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THC
by: Oksana Fihurka, et al.
Published: (2022-04-01)

Differential Cellular and Molecular Effects of Butyrate and Trichostatin A on Vascular Smooth Muscle Cells
by: Kasturi Ranganna, et al.
Published: (2012-09-01)

Phenotypic Plasticity in Morphological Traits of <i>Abelmoschus esculentus</i> L. Induced by Histone Deacetylase Inhibitor, Trichostatin A
by: Sasipriya Sasikumar, et al.
Published: (2022-09-01)

The neuroprotective effects of Liuwei Dihuang medicine in the APP/PS1 mouse model are dependent on the PI3K/Akt signaling pathway
by: Ye Yuan, et al.
Published: (2023-10-01)

<i>Humulus lupulus</i> L. Extract Protects against Senior Osteoporosis through Inhibiting Amyloid <i>β</i> Deposition and Oxidative Stress in APP/PS1 Mutated Transgenic Mice and Osteoblasts
by: Tianshuang Xia, et al.
Published: (2023-01-01)

Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response
by: Nancy R. Stallings, et al.
Published: (2023-10-01)

Effect of Trichostatin A on Histone Deacetylases 1, 2 and 3, p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2 Gene Expression in Breast Cancer SK-BR-3 Cell Line
by: Masumeh Sanaei, et al.
Published: (2020-06-01)

Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology
by: Yuqing Liu, et al.
Published: (2023-04-01)

Molecular Biology of Alzheimer’s Disease
by: M. Baki Yokeş, et al.
Published: (2005-04-01)

Trichostatin a restores expression of adherens and tight junction proteins during transforming growth factor β-mediated epithelial-to-mesenchymal transition
by: Darshini A Ganatra, et al.
Published: (2018-01-01)

Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer’s mouse model
by: Xixia Chu, et al.
Published: (2022-09-01)

Treadmill Exercise Ameliorates Adult Hippocampal Neurogenesis Possibly by Adjusting the APP Proteolytic Pathway in APP/PS1 Transgenic Mice
by: Haizhen Yu, et al.
Published: (2021-09-01)

Detection of retinal and blood Aβ oligomers with nanobodies
by: Umma Habiba, et al.
Published: (2021-01-01)