Applications of circulating tumor cells for prostate cancer
One of the major challenges that clinicians face is in the difficulties of accurately monitoring disease progression. Prostate cancer is among these diseases and greatly affects the health of men globally. Circulating tumor cells (CTCs) are a rare population of cancer cells that have shed from the p...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-10-01
|
| Series: | Asian Journal of Urology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388216300649 |
| _version_ | 1819150545725685760 |
|---|---|
| author | Shirley Cheng Jie-Fu Chen Yi-Tsung Lu Leland W.K. Chung Hsian-Rong Tseng Edwin M. Posadas |
| author_facet | Shirley Cheng Jie-Fu Chen Yi-Tsung Lu Leland W.K. Chung Hsian-Rong Tseng Edwin M. Posadas |
| author_sort | Shirley Cheng |
| collection | DOAJ |
| description | One of the major challenges that clinicians face is in the difficulties of accurately monitoring disease progression. Prostate cancer is among these diseases and greatly affects the health of men globally. Circulating tumor cells (CTCs) are a rare population of cancer cells that have shed from the primary tumor and entered the peripheral circulation. Not until recently, clinical applications of CTCs have been limited to using enumeration as a prognostic tool in Oncology. However, advances in emerging CTC technologies point toward new applications that could revolutionize the field of prostate cancer. It is now possible to study CTCs as components of a liquid biopsy based on morphological phenotypes, biochemical analyses, and genomic profiling. These advances allow us to gain insight into the heterogeneity and dynamics of cancer biology and to further study the mechanisms behind the evolution of therapeutic resistance. These recent developments utilizing CTCs for clinical applications will greatly impact the future of prostate cancer research and pave the way towards personalized care for men. Keywords: Prostate cancer, Circulating tumor cell, Biomarker, Liquid biopsy, Molecular oncology |
| first_indexed | 2024-12-22T14:19:13Z |
| format | Article |
| id | doaj.art-e28c6231d4c544d390df983fd2f6f1c7 |
| institution | Directory Open Access Journal |
| issn | 2214-3882 |
| language | English |
| last_indexed | 2024-12-22T14:19:13Z |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj.art-e28c6231d4c544d390df983fd2f6f1c72022-12-21T18:23:02ZengElsevierAsian Journal of Urology2214-38822016-10-0134254259Applications of circulating tumor cells for prostate cancerShirley Cheng0Jie-Fu Chen1Yi-Tsung Lu2Leland W.K. Chung3Hsian-Rong Tseng4Edwin M. Posadas5Urologic Oncology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USAUrologic Oncology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Hematology/Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USAUrologic Oncology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Internal Medicine, John H Stroger Hospital, Chicago, IL, USAUrologic Oncology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Hematology/Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USACalifornia Nanosystems Institute, University of California, Los Angeles, CA, USA; Department of Molecular Pharmacology, University of California, Los Angeles, CA, USAUrologic Oncology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Hematology/Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Translational Oncology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Corresponding author. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.One of the major challenges that clinicians face is in the difficulties of accurately monitoring disease progression. Prostate cancer is among these diseases and greatly affects the health of men globally. Circulating tumor cells (CTCs) are a rare population of cancer cells that have shed from the primary tumor and entered the peripheral circulation. Not until recently, clinical applications of CTCs have been limited to using enumeration as a prognostic tool in Oncology. However, advances in emerging CTC technologies point toward new applications that could revolutionize the field of prostate cancer. It is now possible to study CTCs as components of a liquid biopsy based on morphological phenotypes, biochemical analyses, and genomic profiling. These advances allow us to gain insight into the heterogeneity and dynamics of cancer biology and to further study the mechanisms behind the evolution of therapeutic resistance. These recent developments utilizing CTCs for clinical applications will greatly impact the future of prostate cancer research and pave the way towards personalized care for men. Keywords: Prostate cancer, Circulating tumor cell, Biomarker, Liquid biopsy, Molecular oncologyhttp://www.sciencedirect.com/science/article/pii/S2214388216300649 |
| spellingShingle | Shirley Cheng Jie-Fu Chen Yi-Tsung Lu Leland W.K. Chung Hsian-Rong Tseng Edwin M. Posadas Applications of circulating tumor cells for prostate cancer Asian Journal of Urology |
| title | Applications of circulating tumor cells for prostate cancer |
| title_full | Applications of circulating tumor cells for prostate cancer |
| title_fullStr | Applications of circulating tumor cells for prostate cancer |
| title_full_unstemmed | Applications of circulating tumor cells for prostate cancer |
| title_short | Applications of circulating tumor cells for prostate cancer |
| title_sort | applications of circulating tumor cells for prostate cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2214388216300649 |
| work_keys_str_mv | AT shirleycheng applicationsofcirculatingtumorcellsforprostatecancer AT jiefuchen applicationsofcirculatingtumorcellsforprostatecancer AT yitsunglu applicationsofcirculatingtumorcellsforprostatecancer AT lelandwkchung applicationsofcirculatingtumorcellsforprostatecancer AT hsianrongtseng applicationsofcirculatingtumorcellsforprostatecancer AT edwinmposadas applicationsofcirculatingtumorcellsforprostatecancer |