Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases
Magnesium (Mg) is an essential divalent cation involved in various enzymatic reactions that regulate vital biological functions. The main goal was to evaluate Mg status and its association with nutritional indicators in 78 children and adolescents with chronic diseases. We assessed anthropometric, b...
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MDPI AG
2022-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/14/2941 |
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| author | Marlene Fabiola Escobedo-Monge Enrique Barrado Joaquín Parodi-Román María Antonieta Escobedo-Monge María Carmen Torres-Hinojal José Manuel Marugán-Miguelsanz |
| author_facet | Marlene Fabiola Escobedo-Monge Enrique Barrado Joaquín Parodi-Román María Antonieta Escobedo-Monge María Carmen Torres-Hinojal José Manuel Marugán-Miguelsanz |
| author_sort | Marlene Fabiola Escobedo-Monge |
| collection | DOAJ |
| description | Magnesium (Mg) is an essential divalent cation involved in various enzymatic reactions that regulate vital biological functions. The main goal was to evaluate Mg status and its association with nutritional indicators in 78 children and adolescents with chronic diseases. We assessed anthropometric, biochemical, diet, body composition, and bone densitometry valuations. Serum Mg and Ca levels were determined using the standardized method and diet calcium (Ca) and Mg consumption by a prospective 72 h diet survey. Mean serum Ca (9.9 mg/dL), Mg (2.08 mg/dL) dietary Ca (102% DRI: Dietary Reference Intake), and Mg intake (105% DRI) were normal. A total of 45% had hypomagnesemia, 12% had hypermagnesemia, and 26% and 24% had inadequate and high Mg intake, respectively. Only 6% of patients had poor Mg intake and hypomagnesemia, and 54% and 90% of our series had an elevated serum Ca/Mg ratio > 4.70 (mean 4.79) and a low Ca/Mg intake ratio < 1.70 (mean 1.06), respectively. Both Ca/Mg ratios were linked with the risk of developing other chronic conditions such as cardiovascular disease, type 2 diabetes, syndrome metabolic, and even several cancers. Therefore, 79% of children and adolescents with chronic diseases were at elevated risk of having abnormal Mg status and developing other chronic illnesses. |
| first_indexed | 2024-03-09T13:14:05Z |
| format | Article |
| id | doaj.art-e28d28d576c4452bab260062ab5d7048 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T13:14:05Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e28d28d576c4452bab260062ab5d70482023-11-30T21:38:18ZengMDPI AGNutrients2072-66432022-07-011414294110.3390/nu14142941Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic DiseasesMarlene Fabiola Escobedo-Monge0Enrique Barrado1Joaquín Parodi-Román2María Antonieta Escobedo-Monge3María Carmen Torres-Hinojal4José Manuel Marugán-Miguelsanz5Faculty of Medicine, Valladolid University, Avenida Ramón y Cajal, 7, 47005 Valladolid, SpainDepartment of Analytical Chemistry, Science Faculty, Campus Miguel Delibes, University of Valladolid, Calle Paseo de Belén, 7, 47011 Valladolid, SpainScience Faculty, Cadiz University, Paseo de Carlos III, 28, 11003 Cádiz, SpainDepartment of Chemistry, Science Faculty, University of Burgos, Plaza Misael Bañuelos sn, 09001 Burgos, SpainFaculty of Medicine, Valladolid University, Avenida Ramón y Cajal, 7, 47005 Valladolid, SpainDepartment of Pediatrics, Faculty of Medicine, Valladolid University, Avenida Ramón y Cajal, 7, 47005 Valladolid, SpainMagnesium (Mg) is an essential divalent cation involved in various enzymatic reactions that regulate vital biological functions. The main goal was to evaluate Mg status and its association with nutritional indicators in 78 children and adolescents with chronic diseases. We assessed anthropometric, biochemical, diet, body composition, and bone densitometry valuations. Serum Mg and Ca levels were determined using the standardized method and diet calcium (Ca) and Mg consumption by a prospective 72 h diet survey. Mean serum Ca (9.9 mg/dL), Mg (2.08 mg/dL) dietary Ca (102% DRI: Dietary Reference Intake), and Mg intake (105% DRI) were normal. A total of 45% had hypomagnesemia, 12% had hypermagnesemia, and 26% and 24% had inadequate and high Mg intake, respectively. Only 6% of patients had poor Mg intake and hypomagnesemia, and 54% and 90% of our series had an elevated serum Ca/Mg ratio > 4.70 (mean 4.79) and a low Ca/Mg intake ratio < 1.70 (mean 1.06), respectively. Both Ca/Mg ratios were linked with the risk of developing other chronic conditions such as cardiovascular disease, type 2 diabetes, syndrome metabolic, and even several cancers. Therefore, 79% of children and adolescents with chronic diseases were at elevated risk of having abnormal Mg status and developing other chronic illnesses.https://www.mdpi.com/2072-6643/14/14/2941hypomagnesemiahypermagnesemiahypercalcemiadietary magnesium intakesubclinical magnesium deficiency |
| spellingShingle | Marlene Fabiola Escobedo-Monge Enrique Barrado Joaquín Parodi-Román María Antonieta Escobedo-Monge María Carmen Torres-Hinojal José Manuel Marugán-Miguelsanz Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases Nutrients hypomagnesemia hypermagnesemia hypercalcemia dietary magnesium intake subclinical magnesium deficiency |
| title | Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases |
| title_full | Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases |
| title_fullStr | Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases |
| title_full_unstemmed | Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases |
| title_short | Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases |
| title_sort | magnesium status and ca mg ratios in a series of children and adolescents with chronic diseases |
| topic | hypomagnesemia hypermagnesemia hypercalcemia dietary magnesium intake subclinical magnesium deficiency |
| url | https://www.mdpi.com/2072-6643/14/14/2941 |
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