Improved repair of rabbit calvarial defects with hydroxyapatite/chitosan/polycaprolactone composite scaffold-engrafted EPCs and BMSCs

Improved repair of rabbit calvarial defects with hydroxyapatite/chitosan/polycaprolactone composite scaffold-engrafted EPCs and BMSCs

Endothelial progenitor cells (EPCs) expressing vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) and bone marrow mesenchymal stem cells (BMSCs) expressing endogenous bone morphogenetic protein-2 (BMP-2) play the important role in new bone formation. This study inves...

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Bibliographic Details
Main Authors: Hedong Yu, Lingyun Xia, Xieyuan Leng, Yongji Chen, Li Zhang, Xiaobing Ni, Jie Luo, Weidong Leng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
HA/CS/PCL composite scaffold
endothelial progenitor cells
bone marrow mesenchymal stem cells
calvarial defect
BMP-2
VEGF
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.928041/full

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