miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation

miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation

Ovarian dysfunction is a common cause of female infertility, which is associated with genetic, autoimmune and environmental factors. Granulosa cells (GCs) constitute the largest cell population of ovarian follicles. Changes in GCs, including oxidative stress (OS) and excessive reactive oxygen specie...

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Bibliographic Details
Main Authors: Xiaofei Wang, Jiahao Yang, Huiying Li, Hongbei Mu, Ling Zeng, Siying Cai, Ping Su, Huaibiao Li, Ling Zhang, Wenpei Xiang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
miR-484
Oxidative stress
Granulosa cells
Ovarian dysfunction
Mitochondria
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172300085X

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