Rnd3 as a Novel Target to Ameliorate Microvascular Leakage

Rnd3 as a Novel Target to Ameliorate Microvascular Leakage

BackgroundMicrovascular leakage of plasma proteins is a hallmark of inflammation that leads to tissue dysfunction. There are no current therapeutic strategies to reduce microvascular permeability. The purpose of this study was to identify the role of Rnd3, an atypical Rho family GTPase, in the contr...

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Bibliographic Details
Main Authors: Jerome W. Breslin, Dayle A. Daines, Travis M. Doggett, Kristine H. Kurtz, Flavia M. Souza‐Smith, Xun E. Zhang, Mack H. Wu, Sarah Y. Yuan
Format: Article
Language:English
Published: Wiley 2016-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
actin cytoskeleton
inflammation
lamellipodia
microcirculation
microvascular permeability
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.003336

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