Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies
<b>Background:</b> Anxiety has been suggested as a potentially modifiable risk factor for dementia, but results are still controversial. Our main objectives are to develop an updated meta-analysis of prospective population-based studies on the relationship between anxiety and risk of dem...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/6/1791 |
| _version_ | 1797565818992590848 |
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| author | Javier Santabárbara Darren M. Lipnicki Beatriz Olaya Beatriz Villagrasa Juan Bueno-Notivol Lucia Nuez Raúl López-Antón Patricia Gracia-García |
| author_facet | Javier Santabárbara Darren M. Lipnicki Beatriz Olaya Beatriz Villagrasa Juan Bueno-Notivol Lucia Nuez Raúl López-Antón Patricia Gracia-García |
| author_sort | Javier Santabárbara |
| collection | DOAJ |
| description | <b>Background:</b> Anxiety has been suggested as a potentially modifiable risk factor for dementia, but results are still controversial. Our main objectives are to develop an updated meta-analysis of prospective population-based studies on the relationship between anxiety and risk of dementia, and to estimate the population fraction of dementia attributable to anxiety (PAF). <b>Methods:</b> We searched for cohort studies listed on PubMed or Web of Science from January 2018 to January 2020 that reported risk estimates for the association between anxiety and incident dementia. These were added to cohort studies published before January 2018 that were used in a previously published meta-analysis. Fully adjusted RRs were pooled using random effects models. We estimated the proportion of incident dementia attributable to anxiety by using PAF. <b>Results:</b> The meta-analysis included nine prospective cohorts from eight studies, representing 29,608 participants. The overall relative risk (RR) of dementia was 1.24 (95% CI: 1.06–1.46) and the PAF of dementia due to anxiety was 3.9%. <b>Conclusions:</b> Anxiety is significantly associated with an increased risk of all-cause dementia. The treatment or prevention of anxiety might help to reduce dementia incidence rates, but more research is needed to clarify whether anxiety is a cause of dementia rather than a prodrome. |
| first_indexed | 2024-03-10T19:17:25Z |
| format | Article |
| id | doaj.art-e2911698718140029bf343b79fef0deb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:17:25Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e2911698718140029bf343b79fef0deb2023-11-20T03:16:46ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0196179110.3390/jcm9061791Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort StudiesJavier Santabárbara0Darren M. Lipnicki1Beatriz Olaya2Beatriz Villagrasa3Juan Bueno-Notivol4Lucia Nuez5Raúl López-Antón6Patricia Gracia-García7Department of Preventive Medicine and Public Health, Universidad de Zaragoza, 50009 Zaragoza, SpainCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, Randwick, NSW 2052, AustraliaCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, 28029 Madrid, SpainPsychogeriatry, CASM Benito Menni, 08830 Sant Boi de Llobregat, SpainPsychiatry Service, Hospital Universitario Miguel Servet, 50009 Zaragoza, SpainDepartment of Preventive Medicine and Public Health, Universidad de Zaragoza, 50009 Zaragoza, SpainInstituto de Investigación Sanitaria de Aragón (IIS Aragón), 50009 Zaragoza, SpainPsychiatry Service, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain<b>Background:</b> Anxiety has been suggested as a potentially modifiable risk factor for dementia, but results are still controversial. Our main objectives are to develop an updated meta-analysis of prospective population-based studies on the relationship between anxiety and risk of dementia, and to estimate the population fraction of dementia attributable to anxiety (PAF). <b>Methods:</b> We searched for cohort studies listed on PubMed or Web of Science from January 2018 to January 2020 that reported risk estimates for the association between anxiety and incident dementia. These were added to cohort studies published before January 2018 that were used in a previously published meta-analysis. Fully adjusted RRs were pooled using random effects models. We estimated the proportion of incident dementia attributable to anxiety by using PAF. <b>Results:</b> The meta-analysis included nine prospective cohorts from eight studies, representing 29,608 participants. The overall relative risk (RR) of dementia was 1.24 (95% CI: 1.06–1.46) and the PAF of dementia due to anxiety was 3.9%. <b>Conclusions:</b> Anxiety is significantly associated with an increased risk of all-cause dementia. The treatment or prevention of anxiety might help to reduce dementia incidence rates, but more research is needed to clarify whether anxiety is a cause of dementia rather than a prodrome.https://www.mdpi.com/2077-0383/9/6/1791dementiaanxiety disorderrisk factorcohort studymeta-analysis |
| spellingShingle | Javier Santabárbara Darren M. Lipnicki Beatriz Olaya Beatriz Villagrasa Juan Bueno-Notivol Lucia Nuez Raúl López-Antón Patricia Gracia-García Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies Journal of Clinical Medicine dementia anxiety disorder risk factor cohort study meta-analysis |
| title | Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies |
| title_full | Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies |
| title_fullStr | Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies |
| title_full_unstemmed | Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies |
| title_short | Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies |
| title_sort | does anxiety increase the risk of all cause dementia an updated meta analysis of prospective cohort studies |
| topic | dementia anxiety disorder risk factor cohort study meta-analysis |
| url | https://www.mdpi.com/2077-0383/9/6/1791 |
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