Assessing the Costs and Cost-Effectiveness of Genomic Sequencing
Despite dramatic drops in DNA sequencing costs, concerns are great that the integration of genomic sequencing into clinical settings will drastically increase health care expenditures. This commentary presents an overview of what is known about the costs and cost-effectiveness of genomic sequencing....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-4426/5/4/470 |
| _version_ | 1797935351190257664 |
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| author | Kurt D. Christensen Dmitry Dukhovny Uwe Siebert Robert C. Green |
| author_facet | Kurt D. Christensen Dmitry Dukhovny Uwe Siebert Robert C. Green |
| author_sort | Kurt D. Christensen |
| collection | DOAJ |
| description | Despite dramatic drops in DNA sequencing costs, concerns are great that the integration of genomic sequencing into clinical settings will drastically increase health care expenditures. This commentary presents an overview of what is known about the costs and cost-effectiveness of genomic sequencing. We discuss the cost of germline genomic sequencing, addressing factors that have facilitated the decrease in sequencing costs to date and anticipating the factors that will drive sequencing costs in the future. We then address the cost-effectiveness of diagnostic and pharmacogenomic applications of genomic sequencing, with an emphasis on the implications for secondary findings disclosure and the integration of genomic sequencing into general patient care. Throughout, we ground the discussion by describing efforts in the MedSeq Project, an ongoing randomized controlled clinical trial, to understand the costs and cost-effectiveness of integrating whole genome sequencing into cardiology and primary care settings. |
| first_indexed | 2024-04-10T18:13:07Z |
| format | Article |
| id | doaj.art-e2914fc49d924ae098eaead8c0bd6130 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-04-10T18:13:07Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-e2914fc49d924ae098eaead8c0bd61302023-02-02T10:27:18ZengMDPI AGJournal of Personalized Medicine2075-44262015-12-015447048610.3390/jpm5040470jpm5040470Assessing the Costs and Cost-Effectiveness of Genomic SequencingKurt D. Christensen0Dmitry Dukhovny1Uwe Siebert2Robert C. Green3Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USADepartment of Public Health, Medical Decision Making and Health Technology Assessment, University for Health Sciences, Medical Informatics and Technology, Hall in Tirol 6060, AustriaDepartment of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Partners Personalized Medicine, Boston, MA 02115, USADespite dramatic drops in DNA sequencing costs, concerns are great that the integration of genomic sequencing into clinical settings will drastically increase health care expenditures. This commentary presents an overview of what is known about the costs and cost-effectiveness of genomic sequencing. We discuss the cost of germline genomic sequencing, addressing factors that have facilitated the decrease in sequencing costs to date and anticipating the factors that will drive sequencing costs in the future. We then address the cost-effectiveness of diagnostic and pharmacogenomic applications of genomic sequencing, with an emphasis on the implications for secondary findings disclosure and the integration of genomic sequencing into general patient care. Throughout, we ground the discussion by describing efforts in the MedSeq Project, an ongoing randomized controlled clinical trial, to understand the costs and cost-effectiveness of integrating whole genome sequencing into cardiology and primary care settings.http://www.mdpi.com/2075-4426/5/4/470whole genomic sequencingwhole exome sequencingcostcost-effectiveness |
| spellingShingle | Kurt D. Christensen Dmitry Dukhovny Uwe Siebert Robert C. Green Assessing the Costs and Cost-Effectiveness of Genomic Sequencing Journal of Personalized Medicine whole genomic sequencing whole exome sequencing cost cost-effectiveness |
| title | Assessing the Costs and Cost-Effectiveness of Genomic Sequencing |
| title_full | Assessing the Costs and Cost-Effectiveness of Genomic Sequencing |
| title_fullStr | Assessing the Costs and Cost-Effectiveness of Genomic Sequencing |
| title_full_unstemmed | Assessing the Costs and Cost-Effectiveness of Genomic Sequencing |
| title_short | Assessing the Costs and Cost-Effectiveness of Genomic Sequencing |
| title_sort | assessing the costs and cost effectiveness of genomic sequencing |
| topic | whole genomic sequencing whole exome sequencing cost cost-effectiveness |
| url | http://www.mdpi.com/2075-4426/5/4/470 |
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