Sertraline repositioning: an overview of its potential use as a chemotherapeutic agent after four decades of tumor reversal studies

Sertraline repositioning: an overview of its potential use as a chemotherapeutic agent after four decades of tumor reversal studies

Sertraline hydrochloride is a first-line antidepressant with potential antineoplastic properties because of its structural similarity with other drugs capable to inhibit the translation-controlled tumor protein (TCTP), a biomolecule involved in cell proliferation. Recent studies suggest it could be...

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Bibliographic Details
Main Authors: João Luiz Baú-Carneiro, Isabela Akemi Guirao Sumida, Malu Gallon, Tânia Zaleski, Marianna Boia-Ferreira, Francelise Bridi Cavassin
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Translational Oncology
Subjects:
Antidepressant agents
Apoptosis
Neoplasms
Sertraline
TCTP
Drug repurposing
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321002941

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