Molecular adaptations underlying high-frequency hearing in the brain of CF bats species
Abstract Background The majority of bat species have developed remarkable echolocation ability, especially for the laryngeally echolocating bats along with high-frequency hearing. Adaptive evolution has been widely detected for the cochleae in the laryngeally echolocating bats, however, limited unde...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-024-10212-6 |
| _version_ | 1797259534881783808 |
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| author | Xintong Li Hui Wang Xue Wang Mingyue Bao Ruyi Sun Wentao Dai Keping Sun Jiang Feng |
| author_facet | Xintong Li Hui Wang Xue Wang Mingyue Bao Ruyi Sun Wentao Dai Keping Sun Jiang Feng |
| author_sort | Xintong Li |
| collection | DOAJ |
| description | Abstract Background The majority of bat species have developed remarkable echolocation ability, especially for the laryngeally echolocating bats along with high-frequency hearing. Adaptive evolution has been widely detected for the cochleae in the laryngeally echolocating bats, however, limited understanding for the brain which is the central to echolocation signal processing in the auditory perception system, the laryngeally echolocating bats brain may also undergo adaptive changes. Result In order to uncover the molecular adaptations related with high-frequency hearing in the brain of laryngeally echolocating bats, the genes expressed in the brain of Rhinolophus ferrumequinum (CF bat) and Myotis pilosus (FM bat) were both detected and also compared. A total of 346,891 genes were detected and the signal transduction mechanisms were annotated by the most abundant genes, followed by the transcription. In hence, there were 3,088 DEGs were found between the two bat brains, with 1,426 highly expressed in the brain of R. ferrumequinum, which were significantly enriched in the neuron and neurodevelopmental processes. Moreover, we found a key candidate hearing gene, ADCY1, playing an important role in the R. ferrumequinum brain and undergoing adaptive evolution in CF bats. Conclusions Our study provides a new insight to the molecular bases of high-frequency hearing in two laryngeally echolocating bats brain and revealed different nervous system activities during auditory perception in the brain of CF bats. |
| first_indexed | 2024-04-24T23:10:58Z |
| format | Article |
| id | doaj.art-e292ef3f26ed4096aa251a0e572ec1e3 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-04-24T23:10:58Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-e292ef3f26ed4096aa251a0e572ec1e32024-03-17T12:16:30ZengBMCBMC Genomics1471-21642024-03-0125111510.1186/s12864-024-10212-6Molecular adaptations underlying high-frequency hearing in the brain of CF bats speciesXintong Li0Hui Wang1Xue Wang2Mingyue Bao3Ruyi Sun4Wentao Dai5Keping Sun6Jiang Feng7College of Life Science, Jilin Agricultural UniversityCollege of Life Science, Jilin Agricultural UniversityCollege of Life Science, Jilin Agricultural UniversityCollege of Life Science, Jilin Agricultural UniversityCollege of Life Science, Jilin Agricultural UniversityJilin Provincial Key Laboratory of Animal Resource Conservation and Utilization, Northeast Normal UniversityJilin Provincial Key Laboratory of Animal Resource Conservation and Utilization, Northeast Normal UniversityCollege of Life Science, Jilin Agricultural UniversityAbstract Background The majority of bat species have developed remarkable echolocation ability, especially for the laryngeally echolocating bats along with high-frequency hearing. Adaptive evolution has been widely detected for the cochleae in the laryngeally echolocating bats, however, limited understanding for the brain which is the central to echolocation signal processing in the auditory perception system, the laryngeally echolocating bats brain may also undergo adaptive changes. Result In order to uncover the molecular adaptations related with high-frequency hearing in the brain of laryngeally echolocating bats, the genes expressed in the brain of Rhinolophus ferrumequinum (CF bat) and Myotis pilosus (FM bat) were both detected and also compared. A total of 346,891 genes were detected and the signal transduction mechanisms were annotated by the most abundant genes, followed by the transcription. In hence, there were 3,088 DEGs were found between the two bat brains, with 1,426 highly expressed in the brain of R. ferrumequinum, which were significantly enriched in the neuron and neurodevelopmental processes. Moreover, we found a key candidate hearing gene, ADCY1, playing an important role in the R. ferrumequinum brain and undergoing adaptive evolution in CF bats. Conclusions Our study provides a new insight to the molecular bases of high-frequency hearing in two laryngeally echolocating bats brain and revealed different nervous system activities during auditory perception in the brain of CF bats.https://doi.org/10.1186/s12864-024-10212-6BatsBrainEcholocationRNA-SeqAdaptive evolution |
| spellingShingle | Xintong Li Hui Wang Xue Wang Mingyue Bao Ruyi Sun Wentao Dai Keping Sun Jiang Feng Molecular adaptations underlying high-frequency hearing in the brain of CF bats species BMC Genomics Bats Brain Echolocation RNA-Seq Adaptive evolution |
| title | Molecular adaptations underlying high-frequency hearing in the brain of CF bats species |
| title_full | Molecular adaptations underlying high-frequency hearing in the brain of CF bats species |
| title_fullStr | Molecular adaptations underlying high-frequency hearing in the brain of CF bats species |
| title_full_unstemmed | Molecular adaptations underlying high-frequency hearing in the brain of CF bats species |
| title_short | Molecular adaptations underlying high-frequency hearing in the brain of CF bats species |
| title_sort | molecular adaptations underlying high frequency hearing in the brain of cf bats species |
| topic | Bats Brain Echolocation RNA-Seq Adaptive evolution |
| url | https://doi.org/10.1186/s12864-024-10212-6 |
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