Quantitative Evaluation of Intraventricular Delivery of Therapeutic Neural Stem Cells to Orthotopic Glioma

Quantitative Evaluation of Intraventricular Delivery of Therapeutic Neural Stem Cells to Orthotopic Glioma

Neural stem cells (NSCs) are inherently tumor-tropic, which allows them to migrate through normal tissue and selectively localize to invasive tumor sites in the brain. We have engineered a clonal, immortalized allogeneic NSC line (HB1.F3.CD21; CD-NSCs) that maintains its stem-like properties, a norm...

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Bibliographic Details
Main Authors: Margarita Gutova, Linda Flores, Vikram Adhikarla, Lusine Tsaturyan, Revathiswari Tirughana, Soraya Aramburo, Marianne Metz, Joanna Gonzaga, Alexander Annala, Timothy W. Synold, Jana Portnow, Russell C. Rockne, Karen S. Aboody
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Oncology
Subjects:
glioma
neural stem cells
NSCs
intraventricular administration
therapeutic
drug delivery
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00068/full

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