Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial
The probabilistic reward task (PRT) has identified reward learning impairments in those with major depressive disorder (MDD), as well as anhedonia-specific reward learning impairments. However, attempts to validate the anhedonia-specific impairments have produced inconsistent findings. Thus, we seek...
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MDPI AG
2023-07-01
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| Series: | Behavioral Sciences |
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| Online Access: | https://www.mdpi.com/2076-328X/13/8/619 |
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| author | Michael A. Giles Crystal M. Cooper Manish K. Jha Cherise R. Chin Fatt Diego A. Pizzagalli Taryn L. Mayes Christian A. Webb Tracy L. Greer Amit Etkin Joseph M. Trombello Henry W. Chase Mary L. Phillips Melvin G. McInnis Thomas Carmody Phillip Adams Ramin V. Parsey Patrick J. McGrath Myrna Weissman Benji T. Kurian Maurizio Fava Madhukar H. Trivedi |
| author_facet | Michael A. Giles Crystal M. Cooper Manish K. Jha Cherise R. Chin Fatt Diego A. Pizzagalli Taryn L. Mayes Christian A. Webb Tracy L. Greer Amit Etkin Joseph M. Trombello Henry W. Chase Mary L. Phillips Melvin G. McInnis Thomas Carmody Phillip Adams Ramin V. Parsey Patrick J. McGrath Myrna Weissman Benji T. Kurian Maurizio Fava Madhukar H. Trivedi |
| author_sort | Michael A. Giles |
| collection | DOAJ |
| description | The probabilistic reward task (PRT) has identified reward learning impairments in those with major depressive disorder (MDD), as well as anhedonia-specific reward learning impairments. However, attempts to validate the anhedonia-specific impairments have produced inconsistent findings. Thus, we seek to determine whether the Reward Behavior Disengagement (RBD), our proposed economic augmentation of PRT, differs between MDD participants and controls, and whether there is a level at which RBD is high enough for depressed participants to be considered objectively disengaged. Data were gathered as part of the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study, a double-blind, placebo-controlled clinical trial of antidepressant response. Participants included 195 individuals with moderate to severe MDD (Quick Inventory of Depressive Symptomatology (QIDS–SR) score ≥ 15), not in treatment for depression, and with complete PRT data. Healthy controls (<i>n</i> = 40) had no history of psychiatric illness, a QIDS–SR score < 8, and complete PRT data. Participants with MDD were treated with sertraline or placebo for 8 weeks (stage I of the EMBARC trial). RBD was applied to PRT data using discriminant analysis, and classified MDD participants as reward task engaged (<i>n</i> = 137) or reward task disengaged (<i>n</i> = 58), relative to controls. Reward task engaged/disengaged groups were compared on sociodemographic features, reward–behavior, and sertraline/placebo response (Hamilton Depression Rating Scale scores). Reward task disengaged MDD participants responded only to sertraline, whereas those who were reward task engaged responded to sertraline and placebo (<i>F</i>(1293) = 4.33, <i>p</i> = 0.038). Reward task engaged/disengaged groups did not differ otherwise. RBD was predictive of reward impairment in depressed patients and may have clinical utility in identifying patients who will benefit from antidepressants. |
| first_indexed | 2024-03-11T00:07:58Z |
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| id | doaj.art-e29496142eef424a84f8dfe83d86d762 |
| institution | Directory Open Access Journal |
| issn | 2076-328X |
| language | English |
| last_indexed | 2024-03-11T00:07:58Z |
| publishDate | 2023-07-01 |
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| record_format | Article |
| series | Behavioral Sciences |
| spelling | doaj.art-e29496142eef424a84f8dfe83d86d7622023-11-19T00:16:12ZengMDPI AGBehavioral Sciences2076-328X2023-07-0113861910.3390/bs13080619Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC TrialMichael A. Giles0Crystal M. Cooper1Manish K. Jha2Cherise R. Chin Fatt3Diego A. Pizzagalli4Taryn L. Mayes5Christian A. Webb6Tracy L. Greer7Amit Etkin8Joseph M. Trombello9Henry W. Chase10Mary L. Phillips11Melvin G. McInnis12Thomas Carmody13Phillip Adams14Ramin V. Parsey15Patrick J. McGrath16Myrna Weissman17Benji T. Kurian18Maurizio Fava19Madhukar H. Trivedi20Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USACenter for Depression Research and Clinical Care, Peter O’Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USACenter for Depression Research and Clinical Care, Peter O’Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USACenter for Depression Research and Clinical Care, Peter O’Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Psychiatry, Harvard Medical School, Boston, MA 02215, USACenter for Depression Research and Clinical Care, Peter O’Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Psychiatry, Harvard Medical School, Boston, MA 02215, USACenter for Depression Research and Clinical Care, Peter O’Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USACenter for Depression Research and Clinical Care, Peter O’Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Michigan School of Medicine, Ann Arbor, MI 48109, USAPeter O’Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Psychiatry, Columbia University, New York, NY 10032, USADepartment of Psychiatry and Behavioral Health, Stony Brook University Renaissance School of Medicine, Stony Brook, NY 11794, USADepartment of Psychiatry, Columbia University, New York, NY 10032, USADepartment of Psychiatry, Columbia University, New York, NY 10032, USADepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Psychiatry, Harvard Medical School, Boston, MA 02215, USACenter for Depression Research and Clinical Care, Peter O’Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USAThe probabilistic reward task (PRT) has identified reward learning impairments in those with major depressive disorder (MDD), as well as anhedonia-specific reward learning impairments. However, attempts to validate the anhedonia-specific impairments have produced inconsistent findings. Thus, we seek to determine whether the Reward Behavior Disengagement (RBD), our proposed economic augmentation of PRT, differs between MDD participants and controls, and whether there is a level at which RBD is high enough for depressed participants to be considered objectively disengaged. Data were gathered as part of the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study, a double-blind, placebo-controlled clinical trial of antidepressant response. Participants included 195 individuals with moderate to severe MDD (Quick Inventory of Depressive Symptomatology (QIDS–SR) score ≥ 15), not in treatment for depression, and with complete PRT data. Healthy controls (<i>n</i> = 40) had no history of psychiatric illness, a QIDS–SR score < 8, and complete PRT data. Participants with MDD were treated with sertraline or placebo for 8 weeks (stage I of the EMBARC trial). RBD was applied to PRT data using discriminant analysis, and classified MDD participants as reward task engaged (<i>n</i> = 137) or reward task disengaged (<i>n</i> = 58), relative to controls. Reward task engaged/disengaged groups were compared on sociodemographic features, reward–behavior, and sertraline/placebo response (Hamilton Depression Rating Scale scores). Reward task disengaged MDD participants responded only to sertraline, whereas those who were reward task engaged responded to sertraline and placebo (<i>F</i>(1293) = 4.33, <i>p</i> = 0.038). Reward task engaged/disengaged groups did not differ otherwise. RBD was predictive of reward impairment in depressed patients and may have clinical utility in identifying patients who will benefit from antidepressants.https://www.mdpi.com/2076-328X/13/8/619anhedoniamajor depressive disorderprobabilistic reward tasktreatment responsereward engagement |
| spellingShingle | Michael A. Giles Crystal M. Cooper Manish K. Jha Cherise R. Chin Fatt Diego A. Pizzagalli Taryn L. Mayes Christian A. Webb Tracy L. Greer Amit Etkin Joseph M. Trombello Henry W. Chase Mary L. Phillips Melvin G. McInnis Thomas Carmody Phillip Adams Ramin V. Parsey Patrick J. McGrath Myrna Weissman Benji T. Kurian Maurizio Fava Madhukar H. Trivedi Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial Behavioral Sciences anhedonia major depressive disorder probabilistic reward task treatment response reward engagement |
| title | Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial |
| title_full | Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial |
| title_fullStr | Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial |
| title_full_unstemmed | Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial |
| title_short | Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial |
| title_sort | reward behavior disengagement a neuroeconomic model based objective measure of reward pathology in depression findings from the embarc trial |
| topic | anhedonia major depressive disorder probabilistic reward task treatment response reward engagement |
| url | https://www.mdpi.com/2076-328X/13/8/619 |
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