Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study
Abstract Background Observational epidemiological studies revealed that multiple serum biomarkers can be associated with the risk of oral and oropharyngeal cancer (OC/OPC). However, the causal relationship between them remains largely unknown. This study aimed to investigate the causal relationship...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-023-03729-x |
| _version_ | 1797397782494969856 |
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| author | Weixing Liu Yue Liu Pei Li Zhiyuan Wang Jia Chen Hui Liu Jin Ye |
| author_facet | Weixing Liu Yue Liu Pei Li Zhiyuan Wang Jia Chen Hui Liu Jin Ye |
| author_sort | Weixing Liu |
| collection | DOAJ |
| description | Abstract Background Observational epidemiological studies revealed that multiple serum biomarkers can be associated with the risk of oral and oropharyngeal cancer (OC/OPC). However, the causal relationship between them remains largely unknown. This study aimed to investigate the causal relationship between potential serum biomarkers and (OC/OPC). Methods A two-sample Mendelian randomization (MR) approach was performed to assess the causal association of 10 serum biomarkers with the risk of OC / OPC. Summary data on OC/OPC were obtained from a GWAS meta-analysis that included 2497 cases and 2928 controls. The TwoSampleMR package in R was used to perform MR analyzes. Inverse-variance weighted (IVW), Weighted median and MR-Egger methods were used to assess causal effects. Results Suggestive associations with increased risk of C-reactive protein (CRP) (OR 1.52, 95% CI 1.14 to 2.02), using the IVW method. MR-Egger regression suggested that directional pleiotropy was unlikely to bias the result (P = 0.19). The findings were robust to sensitivity analyzes. The risk of OC/OPC was not associated with serum 25-hydroxyvitamin D, HDL cholesterol, LDL cholesterol, total cholesterol, triglycerides, adiponectin, leptin, HbA1C and Insulin-like growth factor 1 (IGF 1). Conclusions This study supports that CRP was causally associated with an increased risk of oral and oropharyngeal cancer. |
| first_indexed | 2024-03-09T01:15:07Z |
| format | Article |
| id | doaj.art-e2950b7e0a904de2b479a1568242712a |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-09T01:15:07Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-e2950b7e0a904de2b479a1568242712a2023-12-10T12:34:06ZengBMCBMC Oral Health1472-68312023-12-012311710.1186/s12903-023-03729-xCausal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization studyWeixing Liu0Yue Liu1Pei Li2Zhiyuan Wang3Jia Chen4Hui Liu5Jin Ye6Department of Otolaryngology, Head and Neck Surgery, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Otolaryngology, Head and Neck Surgery, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Otolaryngology, Head and Neck Surgery, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Otolaryngology, Head and Neck Surgery, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Otolaryngology, Head and Neck Surgery, Third Affiliated Hospital of Sun Yat-sen UniversityDivision of Pulmonary and Critical Care, Department of Internal Medicine, Third Affiliated Hospital, Sun Yat-sen UniversityDepartment of Otolaryngology, Head and Neck Surgery, Third Affiliated Hospital of Sun Yat-sen UniversityAbstract Background Observational epidemiological studies revealed that multiple serum biomarkers can be associated with the risk of oral and oropharyngeal cancer (OC/OPC). However, the causal relationship between them remains largely unknown. This study aimed to investigate the causal relationship between potential serum biomarkers and (OC/OPC). Methods A two-sample Mendelian randomization (MR) approach was performed to assess the causal association of 10 serum biomarkers with the risk of OC / OPC. Summary data on OC/OPC were obtained from a GWAS meta-analysis that included 2497 cases and 2928 controls. The TwoSampleMR package in R was used to perform MR analyzes. Inverse-variance weighted (IVW), Weighted median and MR-Egger methods were used to assess causal effects. Results Suggestive associations with increased risk of C-reactive protein (CRP) (OR 1.52, 95% CI 1.14 to 2.02), using the IVW method. MR-Egger regression suggested that directional pleiotropy was unlikely to bias the result (P = 0.19). The findings were robust to sensitivity analyzes. The risk of OC/OPC was not associated with serum 25-hydroxyvitamin D, HDL cholesterol, LDL cholesterol, total cholesterol, triglycerides, adiponectin, leptin, HbA1C and Insulin-like growth factor 1 (IGF 1). Conclusions This study supports that CRP was causally associated with an increased risk of oral and oropharyngeal cancer.https://doi.org/10.1186/s12903-023-03729-xSerum biomarkersC-reactive proteinMendelian randomizationOral cancerOropharyngeal cancer |
| spellingShingle | Weixing Liu Yue Liu Pei Li Zhiyuan Wang Jia Chen Hui Liu Jin Ye Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study BMC Oral Health Serum biomarkers C-reactive protein Mendelian randomization Oral cancer Oropharyngeal cancer |
| title | Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study |
| title_full | Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study |
| title_fullStr | Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study |
| title_full_unstemmed | Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study |
| title_short | Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study |
| title_sort | causal association of serum biomarkers with oral cavity and oropharyngeal cancer a mendelian randomization study |
| topic | Serum biomarkers C-reactive protein Mendelian randomization Oral cancer Oropharyngeal cancer |
| url | https://doi.org/10.1186/s12903-023-03729-x |
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