Evidence for presence and functional effects of Kv1.1 channels in β-cells: general survey and results from mceph/mceph mice.
BACKGROUND:Voltage-dependent K(+) channels (Kv) mediate repolarisation of β-cell action potentials, and thereby abrogate insulin secretion. The role of the Kv1.1 K(+) channel in this process is however unclear. We tested for presence of Kv1.1 in different species and tested for a functional role of...
Main Authors: | Zuheng Ma, Catharina Lavebratt, Malin Almgren, Neil Portwood, Lars E Forsberg, Robert Bränström, Erik Berglund, Sture Falkmer, Frank Sundler, Nils Wierup, Anneli Björklund |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-04-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3071710?pdf=render |
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