The cold pressor test in interictal migraine patients – different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system
Abstract Background Data on autonomic nervous system (ANS) activations in migraine patients are quite controversial, with previous studies reporting over- and underactivation of the sympathetic as well as parasympathetic nervous system. In the present study, we explicitly aimed to assess the cranial...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Neurology |
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| Online Access: | http://link.springer.com/article/10.1186/s12883-018-1043-2 |
| _version_ | 1819080558644297728 |
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| author | Ozan E. Eren Ruth Ruscheweyh Christoph Schankin Florian Schöberl Andreas Straube |
| author_facet | Ozan E. Eren Ruth Ruscheweyh Christoph Schankin Florian Schöberl Andreas Straube |
| author_sort | Ozan E. Eren |
| collection | DOAJ |
| description | Abstract Background Data on autonomic nervous system (ANS) activations in migraine patients are quite controversial, with previous studies reporting over- and underactivation of the sympathetic as well as parasympathetic nervous system. In the present study, we explicitly aimed to assess the cranial ANS in migraine patients compared to healthy controls by applying the cold pressor test to a cohort of migraine patients in the interictal phase and measuring the pupillary response. Methods In this prospective observational study, a strong sympathetic stimulus was applied to 20 patients with episodic migraine in the interictal phase and 20 matched controls without migraine, whereby each participant dipped the left hand into ice-cold (4 °C) water for a maximum of 5 min (cold pressor test). At baseline, 2, and 5 min during the cold pressor test, infrared monocular pupillometry was applied to quantify pupil diameter and light reflex parameters. Simultaneously, heart rate and blood pressure were measured by the external brachial RR-method at distinct time intervals to look for at least clinically relevant changes of the cardiovascular ANS. Results There were no significant differences between the migraine patients and controls at baseline and after 2 min of sympathetic stimulation in all the measured pupillary and cardio-vascular parameters. However, at 5 min, pupillary light reflex (PLR) constriction velocity was significantly higher in migraineurs than in controls (5.59 ± 0.73 mm/s vs. 5.16 ± 0.53 mm/s; unpaired t-test p < 0.05), while both cardiovascular parameters and PLR dilatation velocity were similar in both groups at this time point. Conclusions Our findings of an increased PLR constriction velocity after sustained sympathetic stimulation in interictal migraine patients suggest an exaggerated parasympathetic response of the cranial ANS. This indicates that brainstem parasympathetic dysregulation might play a significant role in migraine pathophysiology. More dedicated examination of the ANS in migraine patients might be of value for a deeper understanding of its pathophysiology. |
| first_indexed | 2024-12-21T19:46:48Z |
| format | Article |
| id | doaj.art-e296215f4be744678ba22817b72567f2 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-21T19:46:48Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-e296215f4be744678ba22817b72567f22022-12-21T18:52:18ZengBMCBMC Neurology1471-23772018-04-011811910.1186/s12883-018-1043-2The cold pressor test in interictal migraine patients – different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous systemOzan E. Eren0Ruth Ruscheweyh1Christoph Schankin2Florian Schöberl3Andreas Straube4Department of Neurology, University Hospital, LMU MunichDepartment of Neurology, University Hospital, LMU MunichDepartment of Neurology, Inselspital, Bern University Hospital, University of BernDepartment of Neurology, University Hospital, LMU MunichDepartment of Neurology, University Hospital, LMU MunichAbstract Background Data on autonomic nervous system (ANS) activations in migraine patients are quite controversial, with previous studies reporting over- and underactivation of the sympathetic as well as parasympathetic nervous system. In the present study, we explicitly aimed to assess the cranial ANS in migraine patients compared to healthy controls by applying the cold pressor test to a cohort of migraine patients in the interictal phase and measuring the pupillary response. Methods In this prospective observational study, a strong sympathetic stimulus was applied to 20 patients with episodic migraine in the interictal phase and 20 matched controls without migraine, whereby each participant dipped the left hand into ice-cold (4 °C) water for a maximum of 5 min (cold pressor test). At baseline, 2, and 5 min during the cold pressor test, infrared monocular pupillometry was applied to quantify pupil diameter and light reflex parameters. Simultaneously, heart rate and blood pressure were measured by the external brachial RR-method at distinct time intervals to look for at least clinically relevant changes of the cardiovascular ANS. Results There were no significant differences between the migraine patients and controls at baseline and after 2 min of sympathetic stimulation in all the measured pupillary and cardio-vascular parameters. However, at 5 min, pupillary light reflex (PLR) constriction velocity was significantly higher in migraineurs than in controls (5.59 ± 0.73 mm/s vs. 5.16 ± 0.53 mm/s; unpaired t-test p < 0.05), while both cardiovascular parameters and PLR dilatation velocity were similar in both groups at this time point. Conclusions Our findings of an increased PLR constriction velocity after sustained sympathetic stimulation in interictal migraine patients suggest an exaggerated parasympathetic response of the cranial ANS. This indicates that brainstem parasympathetic dysregulation might play a significant role in migraine pathophysiology. More dedicated examination of the ANS in migraine patients might be of value for a deeper understanding of its pathophysiology.http://link.springer.com/article/10.1186/s12883-018-1043-2MigrainePupillometryAutonomic nervous system (ANS)Parasympathetic nervous system (PSNS)Sympathetic nervous system (SNS)Cold pressor test (CPT) |
| spellingShingle | Ozan E. Eren Ruth Ruscheweyh Christoph Schankin Florian Schöberl Andreas Straube The cold pressor test in interictal migraine patients – different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system BMC Neurology Migraine Pupillometry Autonomic nervous system (ANS) Parasympathetic nervous system (PSNS) Sympathetic nervous system (SNS) Cold pressor test (CPT) |
| title | The cold pressor test in interictal migraine patients – different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system |
| title_full | The cold pressor test in interictal migraine patients – different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system |
| title_fullStr | The cold pressor test in interictal migraine patients – different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system |
| title_full_unstemmed | The cold pressor test in interictal migraine patients – different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system |
| title_short | The cold pressor test in interictal migraine patients – different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system |
| title_sort | cold pressor test in interictal migraine patients different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system |
| topic | Migraine Pupillometry Autonomic nervous system (ANS) Parasympathetic nervous system (PSNS) Sympathetic nervous system (SNS) Cold pressor test (CPT) |
| url | http://link.springer.com/article/10.1186/s12883-018-1043-2 |
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