Progress on potential application of microRNA-107 and B and T lymphocyte attenuator in pancreatic cancer
Pancreatic cancer is one of the common malignant tumors of digestive tract and is difficult to diagnose because it is characterized by insidious onset and asymptomatic early-stage. The diagnosis of pancreatic cancer mainly relies on imaging and serum tumor markers, and the main treatment method is s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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The Editorial Department of Chinese Journal of Clinical Research
2023-09-01
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| Series: | Zhongguo linchuang yanjiu |
| Subjects: | |
| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/view_abstract.aspx?file_no=20230911&flag=1 |
| _version_ | 1797674937048104960 |
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| author | XIE Wenhao ZHAO Haiping JIN Junhua WANG Fei DING Yan |
| author_facet | XIE Wenhao ZHAO Haiping JIN Junhua WANG Fei DING Yan |
| author_sort | XIE Wenhao |
| collection | DOAJ |
| description | Pancreatic cancer is one of the common malignant tumors of digestive tract and is difficult to diagnose because it is characterized by insidious onset and asymptomatic early-stage. The diagnosis of pancreatic cancer mainly relies on imaging and serum tumor markers, and the main treatment method is surgery. However, due to being discovered in the advanced stage of the disease and missing the best opportunity for surgery, the prognosis is extremely poor and short-term survival. Studies have shown that microRNAs (miRNAs, miR) play a key role in the genesis and development of a variety of tumors, of which miR-107 is expressed in pancreatic cancer tissue and blood, which is related to the occurrence and invasion of pancreatic cancer. In some databases, it has been determined that miRNAs can target and regulate B and T lymphocyte attenuator (BTLA). BTLA with its ligand transmits coinhibitory signals and plays a negative regulatory role in the body's anti-tumor immune response, which is related to the immune escape mechanism of tumors and is likely to become a potential target of tumor biotherapy. This article will elaborate miR-107 and BTLA to predict that they may be therapeutic targets of pancreatic cancer and are expected to become diagnostic and prognostic markers of pancreatic cancer.
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| first_indexed | 2024-03-11T22:06:25Z |
| format | Article |
| id | doaj.art-e299002da1db4ea78c1a7b6222ddf35f |
| institution | Directory Open Access Journal |
| issn | 1674-8182 |
| language | zho |
| last_indexed | 2024-03-11T22:06:25Z |
| publishDate | 2023-09-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj.art-e299002da1db4ea78c1a7b6222ddf35f2023-09-25T05:39:23ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822023-09-013691333133710.13429/j.cnki.cjcr.2023.09.011Progress on potential application of microRNA-107 and B and T lymphocyte attenuator in pancreatic cancerXIE Wenhao0ZHAO Haiping1JIN Junhua2WANG Fei3DING Yan4Inner Mongolia Medical University, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China; Hepatobiliary and Pancreatic Surgery Department, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, ChinaHepatobiliary and Pancreatic Surgery Department, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, ChinaHepatobiliary and Pancreatic Surgery Department, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, ChinaHepatobiliary and Pancreatic Surgery Department, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, ChinaInner Mongolia Medical University, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, ChinaPancreatic cancer is one of the common malignant tumors of digestive tract and is difficult to diagnose because it is characterized by insidious onset and asymptomatic early-stage. The diagnosis of pancreatic cancer mainly relies on imaging and serum tumor markers, and the main treatment method is surgery. However, due to being discovered in the advanced stage of the disease and missing the best opportunity for surgery, the prognosis is extremely poor and short-term survival. Studies have shown that microRNAs (miRNAs, miR) play a key role in the genesis and development of a variety of tumors, of which miR-107 is expressed in pancreatic cancer tissue and blood, which is related to the occurrence and invasion of pancreatic cancer. In some databases, it has been determined that miRNAs can target and regulate B and T lymphocyte attenuator (BTLA). BTLA with its ligand transmits coinhibitory signals and plays a negative regulatory role in the body's anti-tumor immune response, which is related to the immune escape mechanism of tumors and is likely to become a potential target of tumor biotherapy. This article will elaborate miR-107 and BTLA to predict that they may be therapeutic targets of pancreatic cancer and are expected to become diagnostic and prognostic markers of pancreatic cancer. http://zglcyj.ijournals.cn/zglcyj/ch/reader/view_abstract.aspx?file_no=20230911&flag=1pancreatic cancermicrornamir-107b and t lymphocyte attenuatorimmunity |
| spellingShingle | XIE Wenhao ZHAO Haiping JIN Junhua WANG Fei DING Yan Progress on potential application of microRNA-107 and B and T lymphocyte attenuator in pancreatic cancer Zhongguo linchuang yanjiu pancreatic cancer microrna mir-107 b and t lymphocyte attenuator immunity |
| title | Progress on potential application of microRNA-107 and B and T lymphocyte attenuator in pancreatic cancer |
| title_full | Progress on potential application of microRNA-107 and B and T lymphocyte attenuator in pancreatic cancer |
| title_fullStr | Progress on potential application of microRNA-107 and B and T lymphocyte attenuator in pancreatic cancer |
| title_full_unstemmed | Progress on potential application of microRNA-107 and B and T lymphocyte attenuator in pancreatic cancer |
| title_short | Progress on potential application of microRNA-107 and B and T lymphocyte attenuator in pancreatic cancer |
| title_sort | progress on potential application of microrna 107 and b and t lymphocyte attenuator in pancreatic cancer |
| topic | pancreatic cancer microrna mir-107 b and t lymphocyte attenuator immunity |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/view_abstract.aspx?file_no=20230911&flag=1 |
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