SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress Sites
DNA lesions have properties that allow them to escape their nuclear compartment to achieve DNA repair in another one. Recent studies uncovered that the replication fork, when its progression is impaired, exhibits increased mobility when changing nuclear positioning and anchors to nuclear pore comple...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/12/2010 |
| _version_ | 1797504315312570368 |
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| author | Kamila Schirmeisen Sarah A. E. Lambert Karol Kramarz |
| author_facet | Kamila Schirmeisen Sarah A. E. Lambert Karol Kramarz |
| author_sort | Kamila Schirmeisen |
| collection | DOAJ |
| description | DNA lesions have properties that allow them to escape their nuclear compartment to achieve DNA repair in another one. Recent studies uncovered that the replication fork, when its progression is impaired, exhibits increased mobility when changing nuclear positioning and anchors to nuclear pore complexes, where specific types of homologous recombination pathways take place. In yeast models, increasing evidence points out that nuclear positioning is regulated by small ubiquitin-like modifier (SUMO) metabolism, which is pivotal to maintaining genome integrity at sites of replication stress. Here, we review how SUMO-based pathways are instrumental to spatially segregate the subsequent steps of homologous recombination during replication fork restart. In particular, we discussed how routing towards nuclear pore complex anchorage allows distinct homologous recombination pathways to take place at halted replication forks. |
| first_indexed | 2024-03-10T04:02:53Z |
| format | Article |
| id | doaj.art-e29c9c6dc69d458fbea1a6d88a1163f6 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T04:02:53Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-e29c9c6dc69d458fbea1a6d88a1163f62023-11-23T08:31:38ZengMDPI AGGenes2073-44252021-12-011212201010.3390/genes12122010SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress SitesKamila Schirmeisen0Sarah A. E. Lambert1Karol Kramarz2Institut Curie, Université PSL, CNRS UMR3348, 91400 Orsay, FranceInstitut Curie, Université PSL, CNRS UMR3348, 91400 Orsay, FranceAcademic Excellence Hub—Research Centre for DNA Repair and Replication, University of Wrocław, 50-328 Wrocław, PolandDNA lesions have properties that allow them to escape their nuclear compartment to achieve DNA repair in another one. Recent studies uncovered that the replication fork, when its progression is impaired, exhibits increased mobility when changing nuclear positioning and anchors to nuclear pore complexes, where specific types of homologous recombination pathways take place. In yeast models, increasing evidence points out that nuclear positioning is regulated by small ubiquitin-like modifier (SUMO) metabolism, which is pivotal to maintaining genome integrity at sites of replication stress. Here, we review how SUMO-based pathways are instrumental to spatially segregate the subsequent steps of homologous recombination during replication fork restart. In particular, we discussed how routing towards nuclear pore complex anchorage allows distinct homologous recombination pathways to take place at halted replication forks.https://www.mdpi.com/2073-4425/12/12/2010DNAreplication stressSUMOgenome stabilityhomologous recombinationnuclear pore complex |
| spellingShingle | Kamila Schirmeisen Sarah A. E. Lambert Karol Kramarz SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress Sites Genes DNA replication stress SUMO genome stability homologous recombination nuclear pore complex |
| title | SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress Sites |
| title_full | SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress Sites |
| title_fullStr | SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress Sites |
| title_full_unstemmed | SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress Sites |
| title_short | SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress Sites |
| title_sort | sumo based regulation of nuclear positioning to spatially regulate homologous recombination activities at replication stress sites |
| topic | DNA replication stress SUMO genome stability homologous recombination nuclear pore complex |
| url | https://www.mdpi.com/2073-4425/12/12/2010 |
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