Serum Catestatin Levels Correlate with Ambulatory Blood Pressure and Indices of Arterial Stiffness in Patients with Primary Hypertension
Accumulating data suggests that catestatin, an eclectic neuroendocrine peptide, is involved in the pathophysiology of primary hypertension (PH). Nevertheless, clinical studies concerning its role in PH are still scarce. Therefore, in the present study, we aimed to explore an association between seru...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/9/1204 |
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| author | Marko Kumric Josip Vrdoljak Goran Dujic Daniela Supe-Domic Tina Ticinovic Kurir Zeljko Dujic Josko Bozic |
| author_facet | Marko Kumric Josip Vrdoljak Goran Dujic Daniela Supe-Domic Tina Ticinovic Kurir Zeljko Dujic Josko Bozic |
| author_sort | Marko Kumric |
| collection | DOAJ |
| description | Accumulating data suggests that catestatin, an eclectic neuroendocrine peptide, is involved in the pathophysiology of primary hypertension (PH). Nevertheless, clinical studies concerning its role in PH are still scarce. Therefore, in the present study, we aimed to explore an association between serum catestatin levels, ambulatory blood pressure (BP) and arterial stiffness in patients with PH and healthy controls. In this single-center study, 72 patients aged 40–70 diagnosed with PH, and 72 healthy controls were included. In patients with PH, serum catestatin concentrations were significantly higher in comparison to the healthy controls (29.70 (19.33–49.48) ng/mL vs. 5.83 (4.21–8.29) ng/mL, <i>p</i> < 0.001). Untreated patients had significantly higher serum catestatin than patients treated with antihypertensive drugs (41.61 (22.85–63.83) ng/mL vs. 24.77 (16.41–40.21) ng/mL, <i>p</i> = 0.005). Multiple linear regression analysis showed that serum catestatin levels retained a significant association with mean arterial pressure (β ± standard error, 0.8123 ± 0.3037, <i>p</i> < 0.009) after model adjustments for age, sex and body mass index. Finally, catestatin levels positively correlated with pulse wave velocity (r = 0.496, <i>p</i> < 0.001) and central augmentation index (r = 0.441, <i>p</i> < 0.001), but not with peripheral resistance. In summary, increased serum catestatin concentration in PH, predominantly in the untreated subgroup, and its association with ambulatory BP and arterial stiffness address the role of this peptide in PH. |
| first_indexed | 2024-03-10T00:37:41Z |
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| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T00:37:41Z |
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| series | Biomolecules |
| spelling | doaj.art-e29cc088122840f6a48eea8c14201f0b2023-11-23T15:14:38ZengMDPI AGBiomolecules2218-273X2022-08-01129120410.3390/biom12091204Serum Catestatin Levels Correlate with Ambulatory Blood Pressure and Indices of Arterial Stiffness in Patients with Primary HypertensionMarko Kumric0Josip Vrdoljak1Goran Dujic2Daniela Supe-Domic3Tina Ticinovic Kurir4Zeljko Dujic5Josko Bozic6Department of Pathophysiology, University of Split School of Medicine, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, CroatiaClinical Department of Diagnostic and Interventional Radiology, University Hospital of Split, 21000 Split, CroatiaDepartment of Health Studies, University of Split, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, CroatiaDepartment of Integrative Physiology, University of Split School of Medicine, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, CroatiaAccumulating data suggests that catestatin, an eclectic neuroendocrine peptide, is involved in the pathophysiology of primary hypertension (PH). Nevertheless, clinical studies concerning its role in PH are still scarce. Therefore, in the present study, we aimed to explore an association between serum catestatin levels, ambulatory blood pressure (BP) and arterial stiffness in patients with PH and healthy controls. In this single-center study, 72 patients aged 40–70 diagnosed with PH, and 72 healthy controls were included. In patients with PH, serum catestatin concentrations were significantly higher in comparison to the healthy controls (29.70 (19.33–49.48) ng/mL vs. 5.83 (4.21–8.29) ng/mL, <i>p</i> < 0.001). Untreated patients had significantly higher serum catestatin than patients treated with antihypertensive drugs (41.61 (22.85–63.83) ng/mL vs. 24.77 (16.41–40.21) ng/mL, <i>p</i> = 0.005). Multiple linear regression analysis showed that serum catestatin levels retained a significant association with mean arterial pressure (β ± standard error, 0.8123 ± 0.3037, <i>p</i> < 0.009) after model adjustments for age, sex and body mass index. Finally, catestatin levels positively correlated with pulse wave velocity (r = 0.496, <i>p</i> < 0.001) and central augmentation index (r = 0.441, <i>p</i> < 0.001), but not with peripheral resistance. In summary, increased serum catestatin concentration in PH, predominantly in the untreated subgroup, and its association with ambulatory BP and arterial stiffness address the role of this peptide in PH.https://www.mdpi.com/2218-273X/12/9/1204hypertensioncatestatinchromogranin Acardiovascularbiomarkercatecholamines |
| spellingShingle | Marko Kumric Josip Vrdoljak Goran Dujic Daniela Supe-Domic Tina Ticinovic Kurir Zeljko Dujic Josko Bozic Serum Catestatin Levels Correlate with Ambulatory Blood Pressure and Indices of Arterial Stiffness in Patients with Primary Hypertension Biomolecules hypertension catestatin chromogranin A cardiovascular biomarker catecholamines |
| title | Serum Catestatin Levels Correlate with Ambulatory Blood Pressure and Indices of Arterial Stiffness in Patients with Primary Hypertension |
| title_full | Serum Catestatin Levels Correlate with Ambulatory Blood Pressure and Indices of Arterial Stiffness in Patients with Primary Hypertension |
| title_fullStr | Serum Catestatin Levels Correlate with Ambulatory Blood Pressure and Indices of Arterial Stiffness in Patients with Primary Hypertension |
| title_full_unstemmed | Serum Catestatin Levels Correlate with Ambulatory Blood Pressure and Indices of Arterial Stiffness in Patients with Primary Hypertension |
| title_short | Serum Catestatin Levels Correlate with Ambulatory Blood Pressure and Indices of Arterial Stiffness in Patients with Primary Hypertension |
| title_sort | serum catestatin levels correlate with ambulatory blood pressure and indices of arterial stiffness in patients with primary hypertension |
| topic | hypertension catestatin chromogranin A cardiovascular biomarker catecholamines |
| url | https://www.mdpi.com/2218-273X/12/9/1204 |
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