Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in Mice
Watercress (Nasturtium officinale R. Br.) is an annual plant of the Brasicaceae family. Watercress has efficacy in the treatment of a hypo-allergenic, anti-diabetic, antioxidant, anticancer, and treatment of tuberculosis.The purpose of this research was to determine the potential for acute toxicity...
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| Format: | Article |
| Language: | English |
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Indonesian Society for Cancer Chemoprevention
2016-02-01
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| Series: | ISCC (Indonesian Journal of Cancer Chemoprevention) |
| Online Access: | https://ijcc.chemoprev.org/index.php/ijcc/article/view/97 |
| _version_ | 1817976667513028608 |
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| author | Herawaty Ginting Aminah Dalimunthe Julia Reveny |
| author_facet | Herawaty Ginting Aminah Dalimunthe Julia Reveny |
| author_sort | Herawaty Ginting |
| collection | DOAJ |
| description | Watercress (Nasturtium officinale R. Br.) is an annual plant of the Brasicaceae family. Watercress has efficacy in the treatment of a hypo-allergenic, anti-diabetic, antioxidant, anticancer, and treatment of tuberculosis.The purpose of this research was to determine the potential for acute toxicity of ethanolic extract of watercress. This study aims to observe the histopathology liver , kidney , heart mice and to determine the LD50. Test animals used were 40 male mice and 40 female mice were divided into 8 groups. Group 1 as the control group were given Na – CMC 0,5 % b/v and groups 2-8 were given ethanol extract of watercress herb with a doses of 0,5; 5; 50 ; 500 ; 1000 ; 2000; and 4000 mg/kg bw . LD50 test is determined by the number of deaths in the test group during the 14 days of treatment in the form of one administration of the test materials. Histopathological results at the highest doses showed necrosis and hydropic degeneration of the liver, serosis the kidneys, and the heart inflammation with myofibril irregular heart. LD50 test demonstrated the practical test material is not toxic because no test animals died.
Keywords: acute toxicity, Nasturtium officinale R. Br., Ethanolic extract |
| first_indexed | 2024-04-13T22:05:40Z |
| format | Article |
| id | doaj.art-e29d081bc9be4c4b82f989c647fdf416 |
| institution | Directory Open Access Journal |
| issn | 2088-0197 2355-8989 |
| language | English |
| last_indexed | 2024-04-13T22:05:40Z |
| publishDate | 2016-02-01 |
| publisher | Indonesian Society for Cancer Chemoprevention |
| record_format | Article |
| series | ISCC (Indonesian Journal of Cancer Chemoprevention) |
| spelling | doaj.art-e29d081bc9be4c4b82f989c647fdf4162022-12-22T02:27:57ZengIndonesian Society for Cancer ChemopreventionISCC (Indonesian Journal of Cancer Chemoprevention)2088-01972355-89892016-02-017191610.14499/indonesianjcanchemoprev7iss1pp9-1698Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in MiceHerawaty Ginting0Aminah Dalimunthe1Julia Reveny2Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera UtaraDepartment of Pharmacology, Faculty of Pharmacy, Universitas Sumatera UtaraDepartment of Formulation Technology, Faculty of Pharmacy, Universitas Sumatera UtaraWatercress (Nasturtium officinale R. Br.) is an annual plant of the Brasicaceae family. Watercress has efficacy in the treatment of a hypo-allergenic, anti-diabetic, antioxidant, anticancer, and treatment of tuberculosis.The purpose of this research was to determine the potential for acute toxicity of ethanolic extract of watercress. This study aims to observe the histopathology liver , kidney , heart mice and to determine the LD50. Test animals used were 40 male mice and 40 female mice were divided into 8 groups. Group 1 as the control group were given Na – CMC 0,5 % b/v and groups 2-8 were given ethanol extract of watercress herb with a doses of 0,5; 5; 50 ; 500 ; 1000 ; 2000; and 4000 mg/kg bw . LD50 test is determined by the number of deaths in the test group during the 14 days of treatment in the form of one administration of the test materials. Histopathological results at the highest doses showed necrosis and hydropic degeneration of the liver, serosis the kidneys, and the heart inflammation with myofibril irregular heart. LD50 test demonstrated the practical test material is not toxic because no test animals died. Keywords: acute toxicity, Nasturtium officinale R. Br., Ethanolic extracthttps://ijcc.chemoprev.org/index.php/ijcc/article/view/97 |
| spellingShingle | Herawaty Ginting Aminah Dalimunthe Julia Reveny Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in Mice ISCC (Indonesian Journal of Cancer Chemoprevention) |
| title | Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in Mice |
| title_full | Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in Mice |
| title_fullStr | Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in Mice |
| title_full_unstemmed | Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in Mice |
| title_short | Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in Mice |
| title_sort | acute toxicity effect of the ethanolic extract of watercress herb nasturtium officinale r br in mice |
| url | https://ijcc.chemoprev.org/index.php/ijcc/article/view/97 |
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