The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma

The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma

Abstract Background 5-Fluorouracil (5-FU) is a widely used drug for the therapy of cancer. However, the chemoresistance of tumor cells to 5-FU usually limits its clinical effectiveness. In this study, we explored the role of NLRP3 inflammasome in 5-FU resistance of oral squamous cell carcinoma (OSCC...

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Bibliographic Details
Main Authors: Xiaodong Feng, Qingqiong Luo, Han Zhang, Han Wang, Wantao Chen, Guangxun Meng, Fuxiang Chen
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
NLRP3 inflammasome
5-Fluorouracil
Oral squamous cell carcinoma
Reactive oxygen species
Chemotherapy
Online Access:http://link.springer.com/article/10.1186/s13046-017-0553-x

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