Computerized texture analysis of pulmonary nodules in pediatric patients with osteosarcoma: Differentiation of pulmonary metastases from non-metastatic nodules.
OBJECTIVE:To retrospectively evaluate the value of computerized 3D texture analysis for differentiating pulmonary metastases from non-metastatic lesions in pediatric patients with osteosarcoma. MATERIALS AND METHODS:This retrospective study was approved by the institutional review board. The study c...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0211969 |
| _version_ | 1818403507492880384 |
|---|---|
| author | Yeon Jin Cho Woo Sun Kim Young Hun Choi Ji Young Ha SeungHyun Lee Sang Joon Park Jung-Eun Cheon Hyoung Jin Kang Hee Young Shin In-One Kim |
| author_facet | Yeon Jin Cho Woo Sun Kim Young Hun Choi Ji Young Ha SeungHyun Lee Sang Joon Park Jung-Eun Cheon Hyoung Jin Kang Hee Young Shin In-One Kim |
| author_sort | Yeon Jin Cho |
| collection | DOAJ |
| description | OBJECTIVE:To retrospectively evaluate the value of computerized 3D texture analysis for differentiating pulmonary metastases from non-metastatic lesions in pediatric patients with osteosarcoma. MATERIALS AND METHODS:This retrospective study was approved by the institutional review board. The study comprised 42 pathologically confirmed pulmonary nodules in 16 children with osteosarcoma who had undergone preoperative computed tomography between January 2009 and December 2014. Texture analysis was performed using an in-house program. Multivariate logistic regression analysis was performed to identify factors for differentiating metastatic nodules from non-metastases. A subgroup analysis was performed to identify differentiating parameters in small non-calcified pulmonary nodules. The receiver operator characteristic curve was created to evaluate the discriminating performance of the established model. RESULTS:There were 24 metastatic and 18 non-metastatic lesions. Multivariate analysis revealed that higher mean attenuation (adjusted odds ratio [OR], 1.014, P = 0.003) and larger effective diameter (OR, 1.745, P = 0.012) were significant differentiators. The analysis with small non-calcified pulmonary nodules (7 metastases and 18 non-metastases) revealed significant inter-group differences in various parameters. Logistic regression analysis revealed that higher mean attenuation (OR, 1.007, P = 0.008) was a significant predictor of non-calcified pulmonary metastases. The established logistic regression model of subgroups showed excellent discriminating performance in the ROC analysis (area under the curve, 0.865). CONCLUSION:Pulmonary metastases from osteosarcoma could be differentiated from non-metastases by using computerized texture analysis. Higher mean attenuation and larger diameter were significant predictors for pulmonary metastases, while higher mean attenuation was a significant predictor for small non-calcified pulmonary metastases. |
| first_indexed | 2024-12-14T08:25:21Z |
| format | Article |
| id | doaj.art-e29e0a5bf403466f81790e8418435ec8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T08:25:21Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e29e0a5bf403466f81790e8418435ec82022-12-21T23:09:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01142e021196910.1371/journal.pone.0211969Computerized texture analysis of pulmonary nodules in pediatric patients with osteosarcoma: Differentiation of pulmonary metastases from non-metastatic nodules.Yeon Jin ChoWoo Sun KimYoung Hun ChoiJi Young HaSeungHyun LeeSang Joon ParkJung-Eun CheonHyoung Jin KangHee Young ShinIn-One KimOBJECTIVE:To retrospectively evaluate the value of computerized 3D texture analysis for differentiating pulmonary metastases from non-metastatic lesions in pediatric patients with osteosarcoma. MATERIALS AND METHODS:This retrospective study was approved by the institutional review board. The study comprised 42 pathologically confirmed pulmonary nodules in 16 children with osteosarcoma who had undergone preoperative computed tomography between January 2009 and December 2014. Texture analysis was performed using an in-house program. Multivariate logistic regression analysis was performed to identify factors for differentiating metastatic nodules from non-metastases. A subgroup analysis was performed to identify differentiating parameters in small non-calcified pulmonary nodules. The receiver operator characteristic curve was created to evaluate the discriminating performance of the established model. RESULTS:There were 24 metastatic and 18 non-metastatic lesions. Multivariate analysis revealed that higher mean attenuation (adjusted odds ratio [OR], 1.014, P = 0.003) and larger effective diameter (OR, 1.745, P = 0.012) were significant differentiators. The analysis with small non-calcified pulmonary nodules (7 metastases and 18 non-metastases) revealed significant inter-group differences in various parameters. Logistic regression analysis revealed that higher mean attenuation (OR, 1.007, P = 0.008) was a significant predictor of non-calcified pulmonary metastases. The established logistic regression model of subgroups showed excellent discriminating performance in the ROC analysis (area under the curve, 0.865). CONCLUSION:Pulmonary metastases from osteosarcoma could be differentiated from non-metastases by using computerized texture analysis. Higher mean attenuation and larger diameter were significant predictors for pulmonary metastases, while higher mean attenuation was a significant predictor for small non-calcified pulmonary metastases.https://doi.org/10.1371/journal.pone.0211969 |
| spellingShingle | Yeon Jin Cho Woo Sun Kim Young Hun Choi Ji Young Ha SeungHyun Lee Sang Joon Park Jung-Eun Cheon Hyoung Jin Kang Hee Young Shin In-One Kim Computerized texture analysis of pulmonary nodules in pediatric patients with osteosarcoma: Differentiation of pulmonary metastases from non-metastatic nodules. PLoS ONE |
| title | Computerized texture analysis of pulmonary nodules in pediatric patients with osteosarcoma: Differentiation of pulmonary metastases from non-metastatic nodules. |
| title_full | Computerized texture analysis of pulmonary nodules in pediatric patients with osteosarcoma: Differentiation of pulmonary metastases from non-metastatic nodules. |
| title_fullStr | Computerized texture analysis of pulmonary nodules in pediatric patients with osteosarcoma: Differentiation of pulmonary metastases from non-metastatic nodules. |
| title_full_unstemmed | Computerized texture analysis of pulmonary nodules in pediatric patients with osteosarcoma: Differentiation of pulmonary metastases from non-metastatic nodules. |
| title_short | Computerized texture analysis of pulmonary nodules in pediatric patients with osteosarcoma: Differentiation of pulmonary metastases from non-metastatic nodules. |
| title_sort | computerized texture analysis of pulmonary nodules in pediatric patients with osteosarcoma differentiation of pulmonary metastases from non metastatic nodules |
| url | https://doi.org/10.1371/journal.pone.0211969 |
| work_keys_str_mv | AT yeonjincho computerizedtextureanalysisofpulmonarynodulesinpediatricpatientswithosteosarcomadifferentiationofpulmonarymetastasesfromnonmetastaticnodules AT woosunkim computerizedtextureanalysisofpulmonarynodulesinpediatricpatientswithosteosarcomadifferentiationofpulmonarymetastasesfromnonmetastaticnodules AT younghunchoi computerizedtextureanalysisofpulmonarynodulesinpediatricpatientswithosteosarcomadifferentiationofpulmonarymetastasesfromnonmetastaticnodules AT jiyoungha computerizedtextureanalysisofpulmonarynodulesinpediatricpatientswithosteosarcomadifferentiationofpulmonarymetastasesfromnonmetastaticnodules AT seunghyunlee computerizedtextureanalysisofpulmonarynodulesinpediatricpatientswithosteosarcomadifferentiationofpulmonarymetastasesfromnonmetastaticnodules AT sangjoonpark computerizedtextureanalysisofpulmonarynodulesinpediatricpatientswithosteosarcomadifferentiationofpulmonarymetastasesfromnonmetastaticnodules AT jungeuncheon computerizedtextureanalysisofpulmonarynodulesinpediatricpatientswithosteosarcomadifferentiationofpulmonarymetastasesfromnonmetastaticnodules AT hyoungjinkang computerizedtextureanalysisofpulmonarynodulesinpediatricpatientswithosteosarcomadifferentiationofpulmonarymetastasesfromnonmetastaticnodules AT heeyoungshin computerizedtextureanalysisofpulmonarynodulesinpediatricpatientswithosteosarcomadifferentiationofpulmonarymetastasesfromnonmetastaticnodules AT inonekim computerizedtextureanalysisofpulmonarynodulesinpediatricpatientswithosteosarcomadifferentiationofpulmonarymetastasesfromnonmetastaticnodules |