Clinical, electrophysiological, and histopathological profile of biopsy-proven vasculitic neuropathy
Background: Vasculitic neuropathies are an uncommon heterogeneous group of nerve disorders characterized by inflammation of the vasa nervorum, which may be either systemic vasculitic neuropathy (SVN) or non-SVN (NSVN). Settings and Design: This is a retrospective, observational study. Materials and...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | CHRISMED Journal of Health and Research |
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| Online Access: | http://www.cjhr.org/article.asp?issn=2348-3334;year=2020;volume=7;issue=2;spage=130;epage=134;aulast=Deolalikar |
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| author | Suchitra Deolalikar Preethi A M. Paul Vineeth Jaison Jayshree Nandi Deepti Arora Jeyaraj D Pandian Mahesh P Kate |
| author_facet | Suchitra Deolalikar Preethi A M. Paul Vineeth Jaison Jayshree Nandi Deepti Arora Jeyaraj D Pandian Mahesh P Kate |
| author_sort | Suchitra Deolalikar |
| collection | DOAJ |
| description | Background: Vasculitic neuropathies are an uncommon heterogeneous group of nerve disorders characterized by inflammation of the vasa nervorum, which may be either systemic vasculitic neuropathy (SVN) or non-SVN (NSVN). Settings and Design: This is a retrospective, observational study. Materials and Methods: Nerve biopsy-proven cases of vasculitic neuropathy (VN) from January 2011 to December 2017 were included in the study. Results: Twenty-five percent (40/156) patients had vasculitis on biopsy, 62.5% were male and the mean age was 52.8 ± 14.9 years. The median (interquartile range) duration of symptoms before diagnosis was 75 (345) days. Thirty (75%) patients had NSVN and 10 (25%) patients had SVN. The clinical pattern of peripheral nervous system involvement was as follows: 20 (50%) had polyneuropathy, 13 (32.5%) had mononeuritis multiplex, and 7 (32.5%) had polyradiculoneuropathy. Twenty-three (57.5%) patients received immunomodulatory therapy. Conclusion: VN has a wide spectrum of clinical presentation. High index of suspicion followed by nerve biopsy is needed for diagnosis. Early treatment may improve prognosis in this group of patients. |
| first_indexed | 2024-12-21T12:25:04Z |
| format | Article |
| id | doaj.art-e29e482efaa34115a480ba793fefa631 |
| institution | Directory Open Access Journal |
| issn | 2348-3334 2348-506X |
| language | English |
| last_indexed | 2024-12-21T12:25:04Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | CHRISMED Journal of Health and Research |
| spelling | doaj.art-e29e482efaa34115a480ba793fefa6312022-12-21T19:04:13ZengWolters Kluwer Medknow PublicationsCHRISMED Journal of Health and Research2348-33342348-506X2020-01-017213013410.4103/cjhr.cjhr_34_19Clinical, electrophysiological, and histopathological profile of biopsy-proven vasculitic neuropathySuchitra DeolalikarPreethi A M. PaulVineeth JaisonJayshree NandiDeepti AroraJeyaraj D PandianMahesh P KateBackground: Vasculitic neuropathies are an uncommon heterogeneous group of nerve disorders characterized by inflammation of the vasa nervorum, which may be either systemic vasculitic neuropathy (SVN) or non-SVN (NSVN). Settings and Design: This is a retrospective, observational study. Materials and Methods: Nerve biopsy-proven cases of vasculitic neuropathy (VN) from January 2011 to December 2017 were included in the study. Results: Twenty-five percent (40/156) patients had vasculitis on biopsy, 62.5% were male and the mean age was 52.8 ± 14.9 years. The median (interquartile range) duration of symptoms before diagnosis was 75 (345) days. Thirty (75%) patients had NSVN and 10 (25%) patients had SVN. The clinical pattern of peripheral nervous system involvement was as follows: 20 (50%) had polyneuropathy, 13 (32.5%) had mononeuritis multiplex, and 7 (32.5%) had polyradiculoneuropathy. Twenty-three (57.5%) patients received immunomodulatory therapy. Conclusion: VN has a wide spectrum of clinical presentation. High index of suspicion followed by nerve biopsy is needed for diagnosis. Early treatment may improve prognosis in this group of patients.http://www.cjhr.org/article.asp?issn=2348-3334;year=2020;volume=7;issue=2;spage=130;epage=134;aulast=Deolalikarnerve biopsypolyneuropathyvasculitic neuropathy |
| spellingShingle | Suchitra Deolalikar Preethi A M. Paul Vineeth Jaison Jayshree Nandi Deepti Arora Jeyaraj D Pandian Mahesh P Kate Clinical, electrophysiological, and histopathological profile of biopsy-proven vasculitic neuropathy CHRISMED Journal of Health and Research nerve biopsy polyneuropathy vasculitic neuropathy |
| title | Clinical, electrophysiological, and histopathological profile of biopsy-proven vasculitic neuropathy |
| title_full | Clinical, electrophysiological, and histopathological profile of biopsy-proven vasculitic neuropathy |
| title_fullStr | Clinical, electrophysiological, and histopathological profile of biopsy-proven vasculitic neuropathy |
| title_full_unstemmed | Clinical, electrophysiological, and histopathological profile of biopsy-proven vasculitic neuropathy |
| title_short | Clinical, electrophysiological, and histopathological profile of biopsy-proven vasculitic neuropathy |
| title_sort | clinical electrophysiological and histopathological profile of biopsy proven vasculitic neuropathy |
| topic | nerve biopsy polyneuropathy vasculitic neuropathy |
| url | http://www.cjhr.org/article.asp?issn=2348-3334;year=2020;volume=7;issue=2;spage=130;epage=134;aulast=Deolalikar |
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