Production of constrained L-cyclo-tetrapeptides by epimerization-resistant direct aminolysis
Abstract The synthesis of constrained 12-membered rings is notably difficult. The main challenges result from constraints during the linear peptide cyclization. Attempts to overcome constraints through excessive activation frequently cause peptidyl epimerization, while insufficient activation of the...
| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado: |
Nature Portfolio
2024-06-01
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| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-024-49329-3 |